Neurologie

Die Schwerpunkte der neurologischen Forschung liegen auf Multipler Sclerose (MS) und Hirnschlag. Die Datenzentren der jeweiligen nationalen Kohorte "MS Cohort Study" und des Registers "Swiss Stroke Registry" liegen beim DKF. Weitere Themengebiete sind die Erforschung von Macula- und Retinadegeneration, von Gliomas und diverse Fragestellungen in der Altersmedizin. In der pädiatrischen Neurologie widmen sich die Forschungsgruppen der Muskeldystrophie Duchenne, der Epilepsie, sowie der Multiplen Sclerose und Anorexia nervosa.

Auswahl aktueller Publikationen

Anti-GABAA receptor encephalitis 14 months after allogeneic haematopoietic stem-cell transplant for acute myeloid leukaemia. Rusche T, Yaldizli Ö, Galbusera R, Mutke M, Halter JP, Lieb J, Matteazzi F, Stelmes A, Bittner J, Grzonka P, Frank N, Cordier D, Hench J, Frank S, Hirsch HH, Fischer U, Kuhle J, Sutter R, Rüegg S, Fisch U. Lancet. 2024 Feb 3;403(10425):469-470. doi: 10.1016/S0140-6736(23)02831-3. PMID: 38309783.

Complement Activation Is Associated With Disease Severity in Multiple Sclerosis. Oechtering J, Stein K, Schaedelin SA, Maceski AM, Orleth A, Meier S, Willemse E, Qureshi F, Heijnen I, Regeniter A, Derfuss T, Benkert P, D'Souza M, Limberg M, Fischer-Barnicol B, Achtnichts L, Mueller S, Salmen A, Lalive PH, Bridel C, Pot C, Du Pasquier RA, Gobbi C, Wiendl H, Granziera C, Kappos L, Trendelenburg M, Leppert D, Luenemann JD, Kuhle J; Swiss MS Cohort Study. Neurol Neuroimmunol Neuroinflamm. 2024 Mar;11(2):e200212. doi: 10.1212/NXI.0000000000200212. Epub 2024 Feb 14. PMID: 38354323.

Toward Individual Treatment in Cervical Artery Dissection: Subgroup Analysis of the TREAT-CAD Randomized Trial. Kaufmann JE, Gensicke H, Schaedelin S, Luft AR, Goeggel-Simonetti B, Fischer U, Michel P, Strambo D, Kägi G, Vehoff J, Nedeltchev K, Kahles T, Kellert L, Rosenbaum S, von Rennenberg R, Riegler C, Seiffge D, Sarikaya H, Zietz A, Wischmann J, Polymeris AA, Hänsel M, Globas C, Bonati LH, Brehm A, De Marchis GM, Peters N, Nolte CH, Christensen H, Wegener S, Psychogios MN, Arnold M, Lyrer P, Traenka C, Engelter ST; TREAT-CAD Trial. Ann Neurol. 2024 Feb 16. doi: 10.1002/ana.26886. Epub ahead of print. PMID: 38362818.

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis. Cagol A, Cortese R, Barakovic M, Schaedelin S, Ruberte E, Absinta M, Barkhof F, Calabrese M, Castellaro M, Ciccarelli O, Cocozza S, De Stefano N, Enzinger C, Filippi M, Jurynczyk M, Maggi P, Mahmoudi N, Messina S, Montalban X, Palace J, Pontillo G, Pröbstel AK, Rocca MA, Ropele S, Rovira À, Schoonheim MM, Sowa P, Strijbis E, Wattjes MP, Sormani MP, Kappos L, Granziera C; MAGNIMS Study Group. JAMA Neurol. 2023 Dec 11:e234737. doi: 10.1001/jamaneurol.2023.4737. Epub ahead of print. PMID: 38079177; PMCID: PMC10714285.

Ongoing Challenges in the Diagnosis of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. Lipps P, Ayroza Galvão Ribeiro Gomes AB, Kulsvehagen L, Mutke MA, Kuhle J, Papadopoulou A, Pröbstel AK. JAMA Neurol. 2023 Oct 10:e233956. doi: 10.1001/jamaneurol.2023.3956. Epub ahead of print. PMID: 37814961; PMCID: PMC10565644.

Safety and efficacy of tamoxifen in boys with Duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Henzi BC, Schmidt S, Nagy S, Rubino-Nacht D, Schaedelin S, Putananickal N, Stimpson G; North Star Consortium; Amthor H, Childs AM, Deconinck N, de Groot I, Horrocks I, Houwen-van Opstal S, Laugel V, Lopez Lobato M, Madruga Garrido M, Nascimento Osorio A, Schara-Schmidt U, Spinty S, von Moers A, Lawrence F, Hafner P, Dorchies OM, Fischer D. Lancet Neurol. 2023 Oct;22(10):890-899. doi: 10.1016/S1474-4422(23)00285-5. PMID: 37739572.

Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination. Ayroza Galvão Ribeiro Gomes AB, Kulsvehagen L, Lipps P, Cagol A, Cerdá-Fuertes N, Neziraj T, Flammer J, Lerner J, Lecourt AC, de Oliveira S Siebenborn N, Cortese R, Schaedelin S, Andreoli Schoeps V, de Moura Brasil Matos A, Trombini Mendes N, Dos Reis Pereira C, Ribeiro Monteiro ML, Dos Apóstolos-Pereira SL, Schindler P, Chien C, Schwake C, Schneider R, Pakeerathan T, Aktas O, Fischer U, Mehling M, Derfuss T, Kappos L, Ayzenberg I, Ringelstein M, Paul F, Callegaro D, Kuhle J, Papadopoulou A, Granziera C, Pröbstel AK. JAMA Neurol. 2023 Sep 1;80(9):989-995. doi: 10.1001/jamaneurol.2023.2523. PMID: 37548987; PMCID: PMC10407763.

Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial. Polymeris AA, Karwacki GM, Siepen BM, Schaedelin S, Tsakiris DA, Stippich C, Guzman R, Nickel CH, Sprigg N, Kägi G, Vehoff J, Barinka F, Thilemann S, Maurer M, Wagner B, Traenka C, Gensicke H, De Marchis GMBonati LHFischer U, Z'Graggen WJ, Nedeltchev K, Wegener S, Baumgartner P, Engelter ST, Seiffge DJ, Peters N, Lyrer PA; TICH-NOAC Investigators. Stroke. 2023 Sep;54(9):2223-2234. Epub 2023 Jul 19.

Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation; Baumann SM, De Stefano P, Kliem PSC, Grzonka P, Gebhard CE, Sarbu OE, De Marchis GMHunziker S, Rüegg S, Kleinschmidt A, Pugin J, Quintard H, Marsch S, Seeck M, Sutter R.; Crit Care. 2023 Aug 5;27(1):308. doi: 10.1186/s13054-023-04592-6. PMID: 37543625; PMCID: PMC10403848

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation Fischer U, Koga M, Strbian D, Branca M, Abend S, Trelle S, Paciaroni M, Thomalla G, Michel P, Nedeltchev K, Bonati LH, Ntaios G, Gattringer T, Sandset EC, Kelly P, Lemmens R, Sylaja PN, Aguiar de Sousa D, Bornstein NM, Gdovinova Z, Yoshimoto T, Tiainen M, Thomas H, Krishnan M, Shim GC, Gumbinger C, Vehoff J, Zhang L, Matsuzono K, Kristoffersen E, Desfontaines P, Vanacker P, Alonso A, Yakushiji Y, Kulyk C, Hemelsoet D, Poli S, Paiva Nunes A, Caracciolo N, Slade P, Demeestere J, Salerno A, Kneihsl M, Kahles T, Giudici D, Tanaka K, Räty S, Hidalgo R, Werring DJ, Göldlin M, Arnold M, Ferrari C, Beyeler S, Fung C, Weder BJ, Tatlisumak T, Fenzl S, Rezny-Kasprzak B, Hakim A, Salanti G, Bassetti C, Gralla J, Seiffge DJ, Horvath T, Dawson J; ELAN Investigators.  N Engl J Med. 2023 Jun 29;388(26):2411-2421. doi: 10.1056/NEJMoa2303048. Epub 2023 May 24. PMID: 37222476.

Incidence and outcome of perforations during medium vessel occlusion compared with large vessel occlusion thrombectomy; Schulze-Zachau V, Brehm A, Ntoulias N, Krug N, Tsogkas I, Blackham KA, Möhlenbruch MA, Jesser J, Cervo A, Kreiser K, Althaus K, Maslias E, Michel P, Saliou G, Riegler C, Nolte CH, Maier I, Jamous A, Rautio R, Ylikotila P, Fargen KM, Wolfe SQ, Castellano D, Boghi A, Kaiser DPO, Cuberi A, Kirschke JS, Schwarting J, Limbucci N, Renieri L, Al Kasab S, Spiotta AM, Fragata I, Rodriquez-Ares T, Maurer CJ, Berlis A, Moreu M, López-Frías A, Pérez-García C, Commodaro C, Pileggi M, Mascitelli J, Giordano F, Casagrande W, Purves CP, Bester M, Flottmann F, Kan PT, Edhayan G, Hofmeister J, Machi P, Kaschner M, Weiss D, Katan MFischer UPsychogios MN.; J Neurointerv Surg. 2023 Jul 31:jnis-2023-020531. Epub ahead of print. 

Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study; Abdelhak A, Petermeier F, Benkert P, Schädelin S, Oechtering J, Maleska Maceski A, Kabesch M, Geis T, Laub O, Leipold G, Gobbi C, Zecca C, Green A, Tumani H, Willemse E, Wiendl H, Granziera C, Kappos L, Leppert D, Waubant E, Wellmann S, Kuhle J.; Lancet Neurol. 2023 Jul 28:S1474-4422(23)00210-7. Epub ahead of print. 

Wearable Sensor Technologies to Assess Motor Functions in People With Multiple Sclerosis: Systematic Scoping Review and Perspective. Woelfle T, Bourguignon L, Lorscheider J, Kappos L, Naegelin Y, Jutzeler CR.; J Med Internet Res. 2023 Jul 27;25:e44428.

Moving toward personalized B cell depletion in multiple sclerosis? Neziraj T, Kappos L,  . 2023 Jun 9;4(6):344-346. doi: 10.1016/j.medj.2023.05.006. PMID: 37301194.

Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis. Leppert D, Watanabe M, Schaedelin S, Piehl F, Furlan R, Gastaldi M, Lambert J, Evertsson B, Fink K, Matsushita T, Masaki K, Isobe N, Kira J, Benkert P, Maceski A, Willemse E, Oechtering J, Orleth A, Meier S, Kuhle JJ Neurol Neurosurg Psychiatry. 2023 Apr 19:jnnp-2022-330796. doi: 10.1136/jnnp-2022-330796. Epub ahead of print. PMID: 37076291.

Atrial Fibrillation Detected before or after Stroke: Role of AnticoagulationLyrer F, Zietz A, Seiffge DJ, Koga M, Volbers B, Wilson D, Bonetti B, Schaedelin S, Gensicke H, Yoshimura S, Macha K, Ambler G, Thilemann S, Dittrich T, Inoue M, Miwa K, Wang R, Siedler G, Biburger L, Brown MM, Jäger RH, Muir K, Traenka C, Tanaka K, Shiozawa M, Bonati LH, Peters N, Lip GYH, Lyrer PA, Cappellari M, Toyoda K, Kallmünzer B, Schwab S, Werring DJ, Engelter ST, De Marchis GM, Polymeris AA; NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, SAMURAI-NVAF and Verona Registry collaborators. Ann Neurol. 2023 Mar 28. doi: 10.1002/ana.26654. Epub ahead of print. PMID: 36975022. 

Personalized maps of T1 relaxometry abnormalities provide correlates of disability in multiple sclerosis patients. Chen X, Schädelin S, Lu PJ, Ocampo-Pineda M, Weigel M, Barakovic M, Ruberte E, Cagol A, Marechal B, Kober T, Kuhle J, Kappos L, Melie-Garcia L, Granziera C. Neuroimage Clin. 2023;37:103349. doi: 10.1016/j.nicl.2023.103349. Epub 2023 Feb 13. PMID: 36801600; PMCID: PMC9958406.

Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis. Meier S, Willemse EAJ, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, Pot C, Salmen A, Disanto G, Zecca C, D'Souza M, Orleth A, Khalil M, Buchmann A, Du Pasquier R, Yaldizli Ö, Derfuss T, Berger K, Hermesdorf M, Wiendl H, Piehl F, Battaglini M, Fischer U, Kappos L, Gobbi C, Granziera C, Bridel C, Leppert D, Maleska Maceski A, Benkert P, Kuhle J. JAMA Neurol. 2023 Feb 6. doi: 10.1001/jamaneurol.2022.5250. Epub ahead of print. PMID: 36745446.

Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial. Roaldsen MB, Eltoft A, Wilsgaard T, Christensen H, Engelter ST, Indredavik B, Jatužis D, Karelis G, Kõrv J, Lundström E, Petersson J, Putaala J, Søyland MH, Tveiten A, Bivard A, Johnsen SH, Mazya MV, Werring DJ, Wu TY, De Marchis GM, Robinson TG, Mathiesen EB; TWIST Investigators. Lancet Neurol. 2023 Feb;22(2):117-126. doi: 10.1016/S1474-4422(22)00484-7. Epub 2022 Dec 19. PMID: 36549308.

Behavioral and neurocognitive effects of judo training on working memory capacity in children with ADHD: A randomized controlled trial. Ludyga S, Mücke M, Leuenberger R, Bruggisser F, Pühse U, Gerber M, Capone-Mori A, Keutler C, Brotzmann M, Weber P. Neuroimage Clin. 2022 Aug 17;36:103156. doi: 10.1016/j.nicl.2022.103156. Epub ahead of print. PMID: 35988343; PMCID: PMC9402389.

Comparison of different clinical risk scores to predict long-term survival and neurological outcome in adults after cardiac arrest: results from a prospective cohort study. Blatter R, Amacher SA, Bohren C, Becker C, Beck K, Gross S, Tisljar K, Sutter R, Marsch S, Hunziker S. Ann Intensive Care. 2022 Aug 17;12(1):77. doi: 10.1186/s13613-022-01048-y. PMID: 35978065; PMCID: PMC9385915.

Brain atrophy measurement over a MRI scanner change in multiple sclerosis. Sinnecker T, Schädelin S, Benkert P, Ruberte E, Amann M, Lieb JM, Naegelin Y, Müller J, Kuhle J, Derfuss T, Kappos L, Wuerfel J, Granziera C, Yaldizli Ö. Neuroimage Clin. 2022 Aug 10;36:103148. doi: 10.1016/j.nicl.2022.103148. Epub ahead of print. PMID: 36007437; PMCID: PMC9424626.

Validation of the Index for Facial Angiofibromas: A new scoring tool to assess facial angiofibromas in the tuberous sclerosis complex. Dill PE, Bessis D, Guidi B, Hadj-Rabia S, Itin P, Koenig MK, Moreno-Artero E, Erlanger TE, Cattaneo M, Weber P, Wataya-Kaneda M. J Am Acad Dermatol. 2022 Aug 5:S0190-9622(22)02418-5. doi: 10.1016/j.jaad.2022.07.041. Epub ahead of print. PMID: 35940368.

Development and implementation of new diagnostic technologies in neurology Granziera C, Woelfle T, Kappos L. Nat Rev Neurol 2022 Aug;18(8):445-446. doi: 10.1038/s41582-022-00692-z.

Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial Fischer U, Kaesmacher J, Strbian D, Eker O, Cognard C, Plattner PS, Bütikofer L, Mordasini P, Deppeler S, Pereira VM, Albucher JF, Darcourt J, Bourcier R, Benoit G, Papagiannaki C, Ozkul-Wermester O, Sibolt G, Tiainen M, Gory B, Richard S, Liman J, Ernst MS, Boulanger M, Barbier C, Mechtouff L, Zhang L, Marnat G, Sibon I, Nikoubashman O, Reich A, Consoli A, Lapergue B, Ribo M, Tomasello A, Saleme S, Macian F, Moulin S, Pagano P, Saliou G, Carrera E, Janot K, Hernández-Pérez M, Pop R, Schiava LD, Luft AR, Piotin M, Gentric JC, Pikula A, Pfeilschifter W, Arnold M, Siddiqui AH, Froehler MT, Furlan AJ, Chapot R, Wiesmann M, Machi P, Diener HC, Kulcsar Z, Bonati LH, Bassetti CL, Mazighi M, Liebeskind DS, Saver JL, Gralla J; SWIFT DIRECT Collaborators. Lancet. 2022 Jul 9;400(10346):104-115.

Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis. Cagol A, Schaedelin S, Barakovic M, Benkert P, Todea RA, Rahmanzadeh R, Galbusera R, Lu PJ, Weigel M, Melie-Garcia L, Ruberte E, Siebenborn N, Battaglini M, Radue EW, Yaldizli Ö, Oechtering J, Sinnecker T, Lorscheider J, Fischer-Barnicol B, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb JM, Remonda L, Wagner F, Vargas MI, Du Pasquier R, Lalive PH, Pravatà E, Weber J, Cattin PC, Gobbi C, Leppert D, Kappos LKuhle J, Granziera C. JAMA Neurol. 2022 May 16. Epub ahead of print.

Aetiology, secondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation. Polymeris AA, Meinel TR, Oehler H, Hölscher K, Zietz A, Scheitz JF, Nolte CH, Stretz C, Yaghi S, Stoll S, Wang R, Häusler KG, Hellwig S, Klammer MG, Litmeier S, Leon Guerrero CR, Moeini-Naghani I, Michel P, Strambo D, Salerno A, Bianco G, Cereda C, Uphaus T, Gröschel K, Katan M, Wegener S, Peters N, Engelter ST, Lyrer PA, Bonati LH, Grunder L, Ringleb PA, Fischer U, Kallmünzer B, Purrucker JC, Seiffge DJ. J Neurol Neurosurg Psychiatry. 2022 Apr 8:jnnp-2021-328391. doi: 10.1136/jnnp-2021-328391. Epub ahead of print. PMID: 35396339.

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study. Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive PH, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle J; NfL Reference Database in the Swiss Multiple Sclerosis Cohort Study Group. Lancet Neurol. 2022 Mar;21(3):246-257. doi: 10.1016/S1474-4422(22)00009-6. PMID: 35182510.

Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis. Müller J, Sinnecker T, Wendebourg MJ, Schläger R, Kuhle J, Schädelin S, Benkert P, Derfuss T, Cattin P, Jud C, Spiess F, Amann M, Lincke T, Barakovic M, Cagol A, Tsagkas C, Parmar K, Pröbstel AK, Reimann S, Asseyer S, Duchow A, Brandt A, Ruprecht K, Hadjikhani N, Fukumoto S, Watanabe M, Masaki K, Matsushita T, Isobe N, Kira JI, Kappos L, Würfel J, Granziera C, Paul F, Yaldizli Ö. Neurol Neuroimmunol Neuroinflamm. 2022 Feb 25;9(3):e1147. doi: 10.1212/NXI.0000000000001147. PMID: 35217580; PMCID: PMC8883575.

Pentosan and Macular Disease-A Causal Association?Scholl HPN, Klaver CCW. JAMA Ophthalmol. 2022 Jan 27. doi: 10.1001/jamaophthalmol.2021.5972. Epub ahead of print. PMID: 35084438.

Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation. Polymeris AA, Macha K, Paciaroni M, Wilson D, Koga M, Cappellari M, Schaedelin S, Zietz A, Peters N, Seiffge DJ, Haupenthal D, Gassmann L, De Marchis GM, Wang R, Gensicke H, Stoll S, Thilemann S, Avramiotis NS, Bonetti B, Tsivgoulis G, Ambler G, Alberti A, Yoshimura S, Brown MM, Shiozawa M, Lip GYH, Venti M, Acciarresi M, Tanaka K, Mosconi MG, Takagi M, Jäger RH, Muir K, Inoue M, Schwab S, Bonati LHLyrer PA, Toyoda K, Caso V, Werring DJ, Kallmünzer B, Engelter ST; NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF and Verona Registry collaborators.
Ann Neurol. 2021 Nov 8. Epub ahead of print.

Longitudinal Changes of Fixation Stability and Location within 24 Months in Stargardt Disease: ProgStar Report No. 16: Short title: Longitudinal Changes of Fixation in Stargardt Disease. Schönbach EM, Strauss RW, Cattaneo MEGV, Fujinami K, Birch DG, Cideciyan AV, Sunness JS, Zrenner E, Sadda SR, Scholl HPN; ProgStar Study Group. Am J Ophthalmol. 2021 Jul 20:S0002-9394(21)00380-9. doi: 10.1016/j.ajo.2021.07.013. Epub ahead of print. PMID: 34298008.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica. Tsagkas C, Schäfer S, Baumgartner A, Müller J, Sinnecker T, Mehling M, van der Stouwe JG, Felder S, Panagiotou A, Potlukova E, Winzeler B, Scholz MC, Timper K, Blackham K, Nickel CH, Christ-Crain M, Bingisser R, Lyrer P, Kappos L, Yaldizli Ö. Lancet. 2021 Jun 5;397(10290):2194. doi: 10.1016/S0140-6736(21)00986-7. PMID: 34090605.

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial. Kappos L, Fox RJ, Burcklen M, Freedman MS, Havrdová EK, Hennessy B, Hohlfeld R, Lublin F, Montalban X, Pozzilli C, Scherz T, D'Ambrosio D, Linscheid P,  Vaclavkova A, Pirozek-Lawniczek M, Kracker H, Sprenger T. JAMA Neurol. 2021 Mar 29 : e210405.J doi: 10.1001/jamaneurol.2021.0405 [Epub ahead of print]

Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: results from the BIOSIGNAL study. Arnold M, Schweizer J, Nakas CT, Schütz V, Westphal LP, Inauen C, Pokorny T, Luft A, Leichtle A, Arnold M, Bicvic A, Fischer U, De Marchis GM, Bonati LH, Müller MD, Kahles T, Nedeltchev K, Cereda CW, Kägi G, Bustamante A, Montaner J, Ntaios G, Foerch C, Spanaus K, von Eckardstein A, Katan M. Eur Heart J. 2021 Mar 8:ehab081. doi: 10.1093/eurheartj/ehab081. Epub ahead of print. PMID: 33709115.

Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sanchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben Assayag E, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Polymeris A, Wagner B, Seiffge DJ, Lyrer P, Algra A, Kappelle LJ, Al-Shahi Salman R, Jäger HR, Lip GYH, Fischer U, El-Koussy M, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Mess WH, Nederkoorn PJ, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra AC, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Hendrikse J, Kelly PJ, Wardlaw J, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Hara H, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network. Lancet Neurol. 2021 Apr;20(4):294-303. doi: 10.1016/S1474-4422(21)00024-7. Epub 2021 Mar 17. PMID: 33743239.

Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial. Engelter ST, Traenka C, Gensicke H, Schaedelin SA, Luft AR, Goeggel Simonetti B, Fischer U, Michel P, Sirimarco G, Kägi G, Vehoff J, Nedeltchev K, Kahles T, Kellert L, Rosenbaum S, von Rennenberg R, Sztajzel R, Leib SL, Jung S, Gralla J, Bruni N, Seiffge D, Feil K, Polymeris AA, Steiner L, Hamann J, Bonati LH, Brehm A, De Marchis GM, Peters N, Stippich C, Nolte CH, Christensen H, Wegener S, Psychogios MN, Arnold M, Lyrer P, on behalf of the TREAT-CAD investigators. Lancet Neurol. 2021 Mar 22; doi.org/10.1016/S1474-4422(21)00044-2

Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study. Hunziker S, Quinto A, Ramin-Wright M, Becker C, Beck K, Vincent A, Tisljar K, Disanto G, Benkert P, Leppert D, Pargger H, Marsch S, Raoul Sutter, Peters N, Kuhle J. Crit Care. 2021 Jan 20;25(1):32. doi: 10.1186/s13054-021-03459-y.

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. Sutter R, Hert L, De Marchis GM, Twerenbold R, Kappos L, Naegelin Y, Kuster GM, Benkert P, Jost J, Maceski AM, Rüegg S, Siegemund M, Leppert D, Tschudin-Sutter S, Kuhle J.  Ann Neurol. 2020 Dec 30. doi: 10.1002/ana.26004. Epub ahead of print. PMID: 33377539.

Accuracy of calculated free valproate levels in adult patients with status epilepticus. Fisch U, Baumann SM, Semmlack S, Marsch S, Rüegg S, Sutter R. Neurology. 2020 Oct 14:10.1212/WNL.0000000000011000. doi: 10.1212/WNL.0000000000011000. Epub ahead of print. PMID: 33055270.

Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates. Alexandros A Polymeris, Michael Coslovksy, Stefanie Aeschbacher, Tim Sinnecker, Pascal Benkert, Richard Kobza, Jürg Beer, Nicolas Rodondi, Urs Fischer, Giorgio Moschovitis, Andreas U Monsch, Anne Springer, Matthias Schwenkglenks, Jens Wuerfel, Gian Marco De Marchis, Philippe A Lyrer, Michael Kühne, Stefan Osswald, David Conen, Jens Kuhle, Leo H Bonati, the SWISS-AF Investigators, , Brain Communications. 2020 October 06, fcaa166.

Ofatumumab versus Teriflunomide in Multiple Sclerosis. Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. PMID: 32757523

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis. Manouchehrinia A, Stridh P, Khademi M, Leppert D, Barro C, Michalak Z, Benkert P, Lycke J, Alfredsson L, Kappos L, Piehl F, Olsson T, Kuhle J, Kockum I.  Neurology. 2020 Jun 9;94(23):e2457-e2467. doi: 10.1212/WNL.0000000000009571. Epub 2020 May 20. PMID: 32434867.

Blood neurofilament light levels segregate treatment effects in multiple sclerosis. Delcoigne B, Manouchehrinia A, Barro C, Benkert P, Michalak Z, Kappos L, Leppert D, Tsai JA, Plavina T, Kieseier BC, Lycke J, Alfredsson L, Kockum I, Kuhle J, Olsson T, Piehl F. Neurology. 2020 Feb 11. pii:10.1212/WNL.0000000000009097. doi: 10.1212/WNL.0000000000009097. [Epub ahead of print]

Serum neurofilament light levels in normal aging and their association with morphologic brain changes. Khalil M, Pirpamer L, Hofer E, Voortman MM, Barro C, Leppert D, Benkert P, Ropele S, Enzinger C, Fazekas F, Schmidt R, Kuhle J. Nat Commun. 2020 Feb 10;11(1):812. doi: 10.1038/s41467-020-14612-6.

Artery occlusion independently predicts unfavorable outcome in cervical artery dissection. Traenka C, Grond-Ginsbach C, Goeggel Simonetti B, Metso TM, Debette S, Pezzini A, Kloss M, Majersik JJ, Southerland AM, Leys D, Baumgartner R, Caso V, Béjot Y, De Marchis GM, Fischer U, Polymeris A, Sarikaya H, Thijs V, Worrall BB, Bersano A, Brandt T, Gensicke H, Bonati LH, Touzeé E, Martin JJ, Chabriat H, Tatlisumak T, Arnold M, Engelter ST, Lyrer P; CADISP-Plus Study Group. Neurology. 2019 Nov 22. pii: 10.1212/WNL.0000000000008654. doi: 10.1212/WNL.0000000000008654. [Epub ahead of print]

Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial. Hafner P, Bonati U, Klein A, Rubino D, Gocheva V, Schmidt S, Schroeder J, Bernert G, Laugel V, Steinlin M, Capone A, Gloor M, Bieri O, Hemkens LG, Speich B, Zumbrunn T, Gueven N, Fischer D. JAMA Netw Open. 2019 Oct 2;2(10):e1914171. doi: 10.1001/jamanetworkopen.2019.14171.

Emergency management of status epilepticus in a high-fidelity simulation: A prospective study. Sutter R, Tisljar K, Opić P, De Marchis GM, Bassetti S, Bingisser R, Hunziker S, Marsch S. Neurology. 2019 Oct 8. pii: 10.1212/WNL.0000000000008461. doi: 10.1212/WNL.0000000000008461. [Epub ahead of print]

Intravenous thrombolysis for suspected ischemic stroke with seizure at onset. Polymeris AA, Curtze S, Erdur H, Hametner C, Heldner MR, Groot AE, Zini A, Béjot Y, Dietrich A, Martinez-Majander N, von Rennenberg R, Gumbinger C, Schaedelin S, De Marchis GM, Thilemann S, Traenka C, Lyrer PA, Bonati LH, Wegener S, Ringleb PA, Tatlisumak T, Nolte CH, Scheitz JF, Arnold M, Strbian D, Nederkoorn PJ, Gensicke H, Engelter ST; TRISP Collaborators. Ann Neurol. 2019 Aug 21. doi: 10.1002/ana.25582. Epub ahead of print

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years. Cantó E, Barro C, Zhao C, Caillier SJ, Michalak Z, Bove R, Tomic D, Santaniello A, Häring DA, Hollenbach J, Henry RG, Cree BAC, Kappos L, Leppert D, Hauser SL, Benkert P, Oksenberg JR, Kuhle J. JAMA Neurol. 2019 Aug 12. doi: 10.1001/jamaneurol.2019.2137. [Epub ahead of print]

Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation. Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Schaedelin S, Shakeshaft C, Takagi M, Tsivgoulis G, Bonetti B, Kallmünzer B, Arihiro S, Alberti A, Polymeris AA, Ambler G, Yoshimura S, Venti M, Bonati LH, Muir KW, Yamagami H, Thilemann S, Altavilla R, Peters N, Inoue M, Bobinger T, Agnelli G, Brown MM, Sato S, Acciarresi M, Jager HR, Bovi P, Schwab S, Lyrer P, Caso V, Toyoda K, Werring DJ, Engelter ST, De Marchis GM; CROMIS-2, RAF, RAF-DOAC, SAMURAI, NOACISP LONGTERM, Erlangen and Verona registry collaborators. Ann Neurol. 2019 Jun;85(6):823-834. doi: 10.1002/ana.25489. Epub 2019 Apr 30.

Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data. Brott TG, Calvet D, Howard G, Gregson J, Algra A, Becquemin JP, de Borst GJ, Bulbulia R, Eckstein HH, Fraedrich G, Greving JP, Halliday A, Hendrikse J, Jansen O, Voeks JH, Ringleb PA, Mas JL, Brown MM, Bonati LH; Carotid Stenosis Trialists' Collaboration. Lancet Neurol. 2019 Apr;18(4):348-356. doi: 10.1016/S1474-4422(19)30028-6. Epub 2019 Feb 6.

A novel biomarker-based prognostic score in acute ischemic stroke: The CoRisk score. De Marchis GM, Dankowski T, König IR, Fladt J, Fluri F, Gensicke H, Foerch C, Findling O, Kurmann R, Fischer U, Luft A, Buhl D, Engelter ST, Lyrer PA, Christ-Crain M, Arnold M, Katan M. Neurology. 2019 Mar 26;92(13):e1517-e1525. doi: 10.1212/WNL.0000000000007177. Epub 2019 Mar 1.