Prof. Dr. med.
Viola Heinzelmann-Schwarz
Position(s)
Co-Director Women’s University Hospital Basel
Head of Gynecology / Gynecological Oncology
Chair in Gynecology
Vice Dean of Research of the Faculty of Medicine
Institution
University Hospital Basel
Phone +41 61 265 90 99
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Research Group Viola Heinzelmann-Schwarz
Research Focus
Oncology & Hematology
Area of Research
Ovarian cancer, gynecological oncology, precision medicine
Approved Research Projects
Clinical
2023- Localized Radiotherapy with concurrent Olaparib in platinum-sensitive recurrent Ovarian cancer vs. standard of care: a randomised multicentre phase II trial (LoRiO)
2022- Molecular profiling and drug prediction in ovarian cancer patients
2021- Vorhersage eines möglichen Ansprechens der Immun-Checkpoint-Inhibitoren-Therapie durch PD-L1 Antikörper beim Eierstockkrebs.
2020- Tumor Profiler (Roche Schweiz AG, ETH Zurich, University Basel, University Zurich, Lotte und Adolf Hotz-Sprenger Stiftung, Baugarten Stiftung, Stiftung für naturwissenschaftliche und technische Forschung.
2019- MATAO Clinical Trial (NCT04111978) (KFS Swiss Cancer Research, Anticancer Fund, Stiftung Fürstlicher Kommerzienrat Giudo Feger.
2019- PHRT Pioneer Project: Dissect longitudinal evolutionary trajectories in ovarian cancer patients using integrated proteo-genomics.
Translational
Besides her clinical research activities Prof. Viola Heinzelmann-Schwarz also leads the “Ovarian Cancer Translational Research Group” at the Department of Biomedicine and as such is closely involved in research projects with patient-related aspects: these projects include studies with patient material (e.g. tumor tissue, circulating tumor cells, blood, ascites), the use of clinic-pathological data from patients, and molecular and epidemiological databases.
2021- Multimodal single-cell surfaceome and transcriptome profiling of longitudinal high-grade ovarian cancer ascites samples.
2021- Innovative ovarian cancer zPDX models for prediction of treatment regime outcomes in precision medicine.
Collaborations
National Collaborations
- MATAO Trial Swiss study centers
- EXPRESSION Trials Swiss study centers
- Tumor Profiler Consortium TPC (ETH Zurich, University Hospital Basel, University of Zurich)
- University of Zurich (Prof. A. Wicki)
- Geneva University Hospital HUG (PD Dr. I. Labidi-Galy)
- ETH Zurich (Prof. N. Aceto, Prof. B. Bodenmiller)
- ZHAW Zurich University of Applied Sciences (Dr. S. Wieser)
- Swiss GO Trial Group (Swiss-GO)
International Collaborations
- MATAO trial study centers in Germany and Austria
- University of New South Wales, Prince of Wales Cancer Centre in Sydney (Prof. M. Friedlander)
- Lowy Cancer Research Centre, University of New South Wales (Dr. C. Ford)
- European Network of Gynecological and Oncological Trial Groups (ENGOT)
- ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ongoing Research Projects
- Tumor Profiler - Molecular dissection of melanoma, ovarian cancer, and AML to genetically and molecularly dissect the tumors on single-cell level as support for clinicians in the best choice of therapy (Tumor Profiler Consortium)
- MATAO Clinical Trial - MAintenance Therapy with Aromatase inhibitor in epithelial Ovarian cancer (MATAO): a randomized double-blinded placebo-controlled multi-center phase III Trial (NCT04111978): PI Prof. Heinzelmann-Schwarz; Sponsor: Swiss GO Trial Group (www.swiss-go.ch)
- Potential of Fourier Transform Infrared (FTIR) spectroscopy as a rapid, non-invasive diagnostic test in urine for endometrial and ovarian cancer: a proof-of-concept (Tilemachos Kavvadias)
Research Team
