Marc Donath

Prof. Dr. med.
Marc Donath

Position(s)
Chief Physician, Clinic of Endocrinology, Diabetes & Metabolism
University Hospital Basel
Research Dean, University of Basel

Institution
University Hospital Basel

Phone +41 61 265 50 78

Email

Research Group Marc Donath

 

Research Focus

Endocrinology, Metabolism & Divelopmental Disorders

Area of Research

Type 2 diabetes, specifically evaluation of new immunomodulatory therapie


Approved Resarch Projects

Only the clinical projects are listed (the major research activity is preclinical):

  • Bicycle Exercise in Newly Diagnosed Diabetics in the Emergency Room
  • Identification of a SIRT1 mutation in a family with type 1 diabetes.
  • Open-label study on treatment of primary aldosteronism with everolimus
  • Postprandial hypoglycemia with anakinra and empagliflozin in patients after bariatric surgery
  • Pancreatic islet transplantation in the anterior chamber of the human eye – a pilot study
  • The role of IL-1 in postprandial fatigue.
  • GLP-1 secretion is regulated by IL-6 signalling: a randomized, placebo-controlled study
  • Exercise and the DPP-IV inhibitor sitagliptin do not improve beta cell function and glucose Homeostasis in long-Lasting Type 1 Diabetes
  • Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
  • Interleukin-1 antagonism in type 1 diabetes of long duration
  • Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes.
  • Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise. A Double Blind, Placebo-Controlled, Randomized Crossover Study
  • Safety, pharmacokinetics, and preliminary efficacy of a specific anti-IL-1alpha therapeutic antibody (MABp1) in patients with type 2 diabetes mellitus
  • Infliximab in the treatment of Crohn disease and type 1 diabetes.
  • Identification of a SIRT1 mutation in a family with type 1 diabetes.

Collaborations

National Collaborations
- National Collaborations with the Endocrinology Clinics of most hospital in Switzerland

International Collaborations
- Multiple International Collaborations


Ongoing Research Projects

  • Open-label study on treatment of primary aldosteronism with everolimus
  • Postprandial hypoglycemia with anakinra and empagliflozin in patients after bariatric surgery.
  • Pancreatic islet transplantation in the anterior chamber of the human eye – a pilot study

Research Team