Research Group Jörg D. Leuppi
Critical Care & Respiratory Medicine
Area of Research
Asthma and COPD, especially predictors of exacerbations and mortality, improving management in primary care practice, optimizing corticosteroid therapy
Approved Research Projects
Ongoing Research Projects
CREATE PRIMA - Clinical Research from multi-modality big data sources without proprietary interfaces in a multicenter Approach
Great opportunities linked with the concept of personalized health care (PHC)
Actual progress in developing novel diagnostic, therapeutic and prognostic strategies currently limited by factors such as
- unavailability of large clinical datasets
- inaccessibility of these data
- existence of data in a variety of different formats
- predominantly unstructured form of that data
- challenges with regards to linking different data sources for profiling individual patients or patient Groups
RECUT - Reduction of corticosteroid use in outpatient treatment of exacerbated COPD
Randomized, double-blind, non-inferiority study in a primary care setting
Aim of the study —Evaluate in a primary care setting, whether an orally administered corticosteroid treatment of three days duration in acute exacerbation of COPD is non-inferior to a five day treatment duration.
- Validation and optimization of International Guidelines in a primary care setting
- Further reduction of cumulative systemic glucocorticoid exposure for COPD patients
Swiss COPD Cohort Study
It is estimated that about 400’000 patients are affected by COPD in Switzerland. Despite the large prevalence long-term data on symptoms and lung function in this population are lacking. Therefore the goal of the SCCS was to assess the situation of COPD care in Switzerland with a particular focus on medical therapy related to GOLD classification.
Patients with a verified COPD diagnosis (FEV1/FVC < 70% without reversibility with bronchodilator [improvement of FEV1 <200ml or < 12%]) were included into the study by general practitioners and pneumologists in Switzerland. Clinical and spirometry exams were performed at baseline and every six months thereafter including information about medical and non-medical therapy, COPD Assessment Test (CAT-Score) and co-morbidities.
Swiss Severe Asthma Registry