Philippe Lyrer

Prof. Dr. med.
Philippe Lyrer

Position(s)
Senior Physician, Deputy Chief of Department Neurology, Head of Stroke Centre

Institution
University Hospital Basel

Phone
+41 61 328 61 60

Email

Research Group Philippe Lyrer

 

Research Focus

Neurology

Area of Research

Clinical stroke research. Carotid and vertebral artery dissection. Genetics in stroke. Thrombolysis and thrombectomy (coagulation inhibition) in acute stroke, evidence-based therapy. Non-vitamin K antagonists and stroke, cerebral hemorrhage, stroke in the elderly, neurorehabilitation after stroke


Approved Research Projects

  • TREAT-CAD (PI) “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD), Co-applicant
  • ESTREL( local PI) “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”, Co-applicant
  • TICH-NOAC (Co-Chair) Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist (TICH-NOAC), Sponsor Investigator
  • TELESTROKE (Chair) Telemedical onsite identification of stroke victims: Stiftung propatient USB, Principal Investigator
  • Metabolic Mechanisms of cerebral small vessel disease, Lab Project, Principal Investigator
  • MAAESTRO “Electronic monitoring and improvement of adherence to direct oral anticoagulant treatment – a randomised crossover study of an educational and reminderbased intervention in ischaemic stroke patients under polypharmacy, Principal Investigator

Investigator-initiated Research Initiatives (European Research Consortia)

  • Cervical Artery Dissection in Ischemic Stroke Patients (CADISP), Founding member, Investigator
  • Thrombolysis in Ischemic Stroke Patients (TRISP), Investigator
  • Novel Oral AntiCoagulants in Stroke Patients (NOACISP), Sponsor Investigator


    Collaborations

    National Collaborations
    - TICH-NOAC (planned to be extended to GB and DK)
    - ESTREL

    International Collaborations
    - ECST-2
    - CADISP (Cervical artery dissection in stroke patients)
    - GLORIA – AF (submitted database analysis and publications)


    Ongoing Research Projects

    • TICH-NOAC: Treatment of cerebral haemorrhage due to NOAC-intake with tranexamid acid, a RCT: accomplishing the goal 109 randomized patients
    • “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”
    • Databank cleaning, adjudication of outcome events “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD)
    • “New Oral Anticoagulants in Stroke Patients” (NOACISP) – acute register and follow –up, completion of follow-up for 1000 patients
    • TELESTROKE: expansion to clinical application
    • ECST-2 The 2nd European Carotid Surgery Trial, sub-Investigator, Steering Committee Member, Adjudicator
    • OPTIMIZE: Prospective non-interventional study for the optimized treatment of refractory hypercholesterolemia in patients with heterozygous familial hypercholesterolemia or clinically apparent atherosclerotic cardiovascular disease with alirocumab (Praluent®)
    • ACTIMIS: randomized, double blind, multicenter, multinational, placebo controlled, single parallel escalating dose safety and efficacy study of act017 used as an add-on therapy on top of standard of care, in the 4.5 hrs post onset of acute ischemic stroke symptoms.
    • Administrative and regulatory support of research projects for members of the stroke team (Twist, TRISP, ACST2, Precise-MRI, ELAN)

    Research Team

    Sebastian Thilemann

    Investigator

    Phone +41 61 328 53 07
    Email

    Dr. med. Christopher Tränka

    Registrar
    Medical Network advisor ESTREL; TREAT-CAD

    Phone +41 61 328 64 02
    Email

    Dr. med. Alexandros Polymeris

    PhD-Student

    Phone +41 61 328 73 19
    Email

    Louisa Meya

    Study Physician , MD-student

    Phone +41 61 556 54 19
    Email

    Fabian Schaub

    Study Physician,MD-Student

    Phone +41 61 328 57 99
    Email

    Dr. Marie-Françoise Ritz

    Project leader

    Phone +41 61 265 38 97
    Email

    Christoph Stippich

    Advisor

    Phone +41 44 255 56 00
    Email

    Prof. Dr. med. Leo Bonati

    Principal Investigator

    Phone +41 61 556 54 42
    Email

    PD Dr. med. Gian Marco DeMarchis

    Principal Investigator

    Phone +41 61 328 73 02
    Email

    PD Dr. med. Henrik Gensicke

    Principal Investigator

    Phone +41 61 328 57 05
    Email

    Benjamin Wagner

    PhD-Student

    Phone +41 61 556 57 07
    Email

    Prof. Dr. med. Stefan Engelter

    Principal Investigator

    Phone +41 61 328 67 51
    Email

    PD Dr. med. Nils Peters

    Principal Investigator

    Phone +41 61 556 58 53
    Email

    Grzegorz Karwacki

    Advisor

    Phone +41 41 205 66 65
    Email

    Dr. med. David Seiffge

    Senior Researcher
    (collaboration with Bern)

    Phone +41 31 664 05 09
    Email

    Marina Maurer

    Study Coordinator

    Phone +41 61 556 50 30
    Email

    Martina Wiegert

    Study Nurse
    Study Coordinator

    Phone +41 61 328 72 79
    Email

    Iris Schneider

    Study Coordinator

    Phone +41 61 328 59 85
    Email

    Caspar Grond-Ginsbach

    Geneticist
    Senior Researcher Stroke Reha FELIXPLATTER

    Phone -
    Email

    Roman Stzajzel

    Advisor

    Phone +41 22 372 33 11
    Email