Johannes van den Anker

Prof. Dr. med.
Johannes van den Anker

Position(s)
Medical Director ASC Head of Pediatric Pharmacology

Institution
University Children's Hospital Basel

Phone
+41 61 704 12 12

Email

Research Group Johannes Van den Anker

 

Research Focus

Clinical Pharmacology

Area of Research

Effects of growth, development and diseases on how to optimize the use of medicines in neonates, infants, children and adolescents; Developmental pharmacology, pharmacometrics & systems pharmacology (computer modeling and simulation), pharmacogenetics, and pharmacoepidemiology; Development of bedside decision support tools to benefit sick children and their caregivers; State-of-the-art cloud based computer lab for systems pharmacology and pharmacometrics research


Approved Research Projects

  • A randomized controlled trial of adjunct corticosteroid therapy in hospitalized children with community acquired pneumonia (CAP): THE KIDS-STEP STUDY
  • Optimizing the use of Methadone in Newborn Infants
  • Metabolism and Toxicity of Acetaminophen in Preterm Infants
  • Pediatric Toxicity and Efficacy in Long-term Systemic Treatment with Anti-sense
  • Postdoctoral Research Training in Pediatric Clinical Pharmacology and Therapeutics
  • Bridging pharmacodynamics biomarkers to clinical outcomes in pediatric inflammatory diseases
  • PK and dosing of metamizole in infants and children; internal funding; co-I
  • KidMaCare study to investigate novel renal biomarkers in healthy infants and children and those with cancer; co-I


    Collaborations

    National Collaborations

    • Leadership role in SNF funded SwissPedPha
    • Collaboration between ETHZ, University of Basel and UKBB has resulted in a multiinvestigator proposal entitled: “Targeting a novel pathway for the treatment for pediatric psoriasis” that was submitted to the BRCCH inaugural funding scheme without receiving funding; This collaboration between Prof Pieters, Carreira and van den Anker will result in finding other funding mechanisms to support this important area in pediatric therapeutics

    International Collaborations

    • Dr. Samira Samiee-Zafarghandy, neonatal medicine specialist, McMaster University, Hamilton, Canada on “the pharmacokinetics of ibuprofen in premature infants with a hemodynamically significant patent ductus arteriosus”; She was awarded a Hamilton Health Sciences New Investigator Fund Grant based on our collaboration.
    • Professor Rebecca Slater, Oxford University, “a PK/PD study following ibuprofen administration in children: linking pain-related changes in brain activity to ibuprofen pharmacokinetics in infants under 3 months old”, Prof Slater and Prof van den Anker are preparing a NICHD application to be submitted 2020.
    • Professor Michael Rieder, London, Ontario and Professor Bruce Carleton, Vancouver, BC and Prof John van den Anker: multiple PIs NICHD R01 application with the general hypothesis “Patients with delayed HSRs to β-lactam antibiotics have a misdirected immune response to reactive drug metabolites of β-lactam antibiotics at the cellular and molecular level” will be submitted November 07, 2019

    Ongoing Research Projects

    • A randomized controlled trial of adjunct corticosteroid therapy in hospitalized children with community acquired pneumonia (CAP): THE KIDS-STEP STUDY, 2017-2022; PI
    • Bridging pharmacodynamics biomarkers to clinical outcomes in pediatric inflammatory diseases, 2016-2021; PI

    Research Team

    Jantine Brussee, PhD

    Postdoc Fellow and Pharmacometrician

    Phone +41 61 704 12 12
    Email

    Verena Gotta, PharmD PhD

    Senior Research Fellow and Pharmacist

    Phone +41 61 704 12 12  
    Email

    Freya Bachmann, MSc

    PhD Student

    Phone -
    Email

    Julia Bielicki, MD MPH

    Research Fellow

    Phone +41 61 704 12 12  
    Email

    Michael Büttcher, MD

    Research Fellow

    Phone +41 61 704 12 12
    Email

    Sarah Koechlin

    Project Manager PharmD MPH

    Phone +41 61 704 12 12
    Email

    Linda Stamm

    Study Nurse

    Phone +41 61 704 12 12  
    Email

    Stephanie Leroux, MD PhD

    Postdoc Fellow, Neonatologist and Pharmacometrician

    Phone +41 61 704 12 12  
    Email

    Andrew Atkinson, PhD

    Postdoc Fellow and
    Biostatistician

    Phone +41 61 704 12 12  
    Email

    Mirjam Pfiffner, PharmD

    PhD Student

    Phone -  
    Email

    Malte Kohns, MD

    Research Fellow

    Phone +41 61 704 12 12
    Email

    Ricarda Foulk

    Project Manager

    Phone +41 61 704 12 12  
    Email

    Regina Santoro

    Study Nurse

    Phone +41 61 704 12 12  
    Email

    Nancy Wochnik

    Study Nurse

    Phone +41 61 704 12 12  
    Email

    Gilbert Koch, PD

    Senior Research Fellow and Mathematician

    Phone +41 61 704 12 12 
    Email

    Tamara van Donge, MSc

    PhD Student

    Phone +41 61 704 12 12
    Email

    Tatjana Welzel, MD

    Research Fellow

    Phone +41 61 704 12 12 
    Email

    Victoria Ziesenitz, MD

    Research Fellow

    Phone +41 61 704 12 12
    Email

    Claudia Werner

    Study Nurse

    Phone +41 61 704 12 12  
    Email

    Aurora Frei

    Study Nurse

    Phone +41 61 704 12 12  
    Email