Klinische Epidemiologie, Public Health & Health Systems

Die Forschungsgruppen dieses Schwerpunkts widmen sich verschiedenen Fragestellungen der Volksgesundheit. Ein Fokus liegt dabei auch auf der Weiterentwicklung von Forschungsmethoden. 


Auswahl aktueller Publikationen

Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE). Imran M, Kwakkenbos L, McCall SJ, McCord KA, Fröbert O, Hemkens LG, Zwarenstein M, Relton C, Rice DB, Langan SM, Benchimol EI, Thabane L, Campbell MK, Sampson M, Erlinge D, Verkooijen HM, Moher D, Boutron I, Ravaud P, Nicholl J, Uher R, Sauvé M, Fletcher J, Torgerson D, Gale C, Juszczak E, Thombs BD. BMJ Open. 2021 Apr 29;11(4):e049093. doi: 10.1136/bmjopen-2021-049093. PMID: 33926985; PMCID: PMC8094349.

CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration. Kwakkenbos L, Imran M, McCall SJ, McCord KA, Fröbert O, Hemkens LG, Zwarenstein M, Relton C, Rice DB, Langan SM, Benchimol EI, Thabane L, Campbell MK, Sampson M, Erlinge D, Verkooijen HM, Moher D, Boutron I, Ravaud P, Nicholl J, Uher R, Sauvé M, Fletcher J, Torgerson D, Gale C, Juszczak E, Thombs BD. BMJ. 2021 Apr 29;373:n857. doi: 10.1136/bmj.n857. PMID: 33926904.

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Axfors C, Schmitt AM, Janiaud P, Van't Hooft J, Abd-Elsalam S, Abdo EF, Abella BS, Akram J, Amaravadi RK, Angus DC, Arabi YM, Azhar S, Baden LR, Baker AW, Belkhir L, Benfield T, Berrevoets MAH, Chen CP, Chen TC, Cheng SH, Cheng CY, Chung WS, Cohen YZ, Cowan LN, Dalgard O, de Almeida E Val FF, de Lacerda MVG, de Melo GC, Derde L, Dubee V, Elfakir A, Gordon AC, Hernandez-Cardenas CM, Hills T, Hoepelman AIM, Huang YW, Igau B, Jin R, Jurado-Camacho F, Khan KS, Kremsner PG, Kreuels B, Kuo CY, Le T, Lin YC, Lin WP, Lin TH, Lyngbakken MN, McArthur C, McVerry BJ, Meza-Meneses P, Monteiro WM, Morpeth SC, Mourad A, Mulligan MJ, Murthy S, Naggie S, Narayanasamy S, Nichol A, Novack LA, O'Brien SM, Okeke NL, Perez L, Perez-Padilla R, Perrin L, Remigio-Luna A, Rivera-Martinez NE, Rockhold FW, Rodriguez-Llamazares S, Rolfe R, Rosa R, Røsjø H, Sampaio VS, Seto TB, Shehzad M, Soliman S, Stout JE, Thirion-Romero I, Troxel AB, Tseng TY, Turner NA, Ulrich RJ, Walsh SR, Webb SA, Weehuizen JM, Velinova M, Wong HL, Wrenn R, Zampieri FG, Zhong W, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. Nat Commun. 2021 Apr 15;12(1):2349. doi: 10.1038/s41467-021-22446-z. PMID: 33859192.

Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study. Mc Cord KA, Ewald H, Agarwal A, Glinz D, Aghlmandi S, Ioannidis JPA, Hemkens LG. BMJ. 2021 Mar 3;372:n450. doi: 10.1136/bmj.n450. PMID: 33658187; PMCID: PMC7926294.

Association of Supporting Trial Evidence and Reimbursement for Off-Label Use of Cancer Drugs. Herbrand AK, Schmitt AM, Briel M, Ewald H, Goldkuhle M, Diem S, Hoogkamer A, Joerger M, Moffa G, Novak U, Hemkens LG, Kasenda B. JAMA Netw Open. 2021 Mar 1;4(3):e210380. doi: 10.1001/jamanetworkopen.2021.0380. PMID: 33651108; PMCID: PMC7926292.

Recruitment and Results Reporting of COVID-19 Randomized Clinical Trials Registered in the First 100 Days of the Pandemic. Janiaud P, Axfors C, Ioannidis JPA, Hemkens LG. JAMA Netw Open. 2021 Mar 1;4(3):e210330. doi: 10.1001/jamanetworkopen.2021.0330. PMID: 33646310.

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis. Janiaud P, Axfors C, Schmitt AM, Gloy V, Ebrahimi F, Hepprich M, Smith ER, Haber NA, Khanna N, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. JAMA. 2021 Feb 26. doi: 10.1001/jama.2021.2747. Epub ahead of print. PMID: 33635310.

Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses. Schandelmaier S, Briel M, Varadhan R, Schmid CH, Devasenapathy N, Hayward RA, Gagnier J, Borenstein M, van der Heijden GJMG, Dahabreh IJ, Sun X, Sauerbrei W, Walsh M, Ioannidis JPA, Thabane L, Guyatt GH. CMAJ. 2020 Aug 10;192(32):E901-E906. doi: 10.1503/cmaj.200077. PMID: 32778601.

Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes: instrument development and reliability study. Devji T, Carrasco-Labra A, Qasim A, Phillips M, Johnston BC, Devasenapathy N, Zeraatkar D, Bhatt M, Jin X, Brignardello-Petersen R, Urquhart O, Foroutan F, Schandelmaier S, Pardo-Hernandez H, Vernooij RW, Huang H, Rizwan Y, Siemieniuk R, Lytvyn L, Patrick DL, Ebrahim S, Furukawa T, Nesrallah G, Schünemann HJ, Bhandari M, Thabane L, Guyatt GH. BMJ. 2020 Jun 4;369:m1714. doi: 10.1136/bmj.m1714. PMID: 32499297; PMCID: PMC7270853.

Online randomized controlled experiments at scale: lessons and extensions to medicine. Kohavi R, Tang D, Xu Y, Hemkens LG, Ioannidis JPA. Trials. 2020 Feb 7;21(1):150. doi: 10.1186/s13063-020-4084-y.

Personalized prediction of smartphone-based psychotherapeutic micro-intervention success using machine learning. Meinlschmidt G, Tegethoff M, Belardi A, Stalujanis E, Oh M, Jung EK, Kim HC, Yoo SS, Lee JH. J Affect Disord. 2019 Nov 14. pii: S0165-0327(19)31212-1. doi: 10.1016/j.jad.2019.11.071. [Epub ahead of print]

Association of Communication Interventions to Discuss Code Status With Patient Decisions for Do-Not-Resuscitate Orders: A Systematic Review and Meta-analysis.Becker C, Lecheler L, Hochstrasser S, Metzger KA, Widmer M, Thommen EB, Nienhaus K, Ewald H, Meier CA, Rueter F, Schaefert R, Bassetti S, Hunziker S. JAMA Network Open. 2019 Jun 5;2(6):e195033. doi: 10.1001/jamanetworkopen.2019.5033.