Christine Bernsmeier

PD Dr. med. Dr. phil.
Christine Bernsmeier

Position(s)
Senior physician
Clarunis Gastroenterology & Hepathology

Institution
University Hospital Basel

Phone +41 61 777 74 16

Email

Research Focus

Immunology & Infectious Diseases

Area of Research

Monocyte and macrophage biology in cirrhosis of the liver.


Approved Research Projects

12/2012 - 11/2014 EASL Sheila Sherlock Postdoctoral Fellowship: "Hepatoadrenal syndrome: Does inflammatory response dysfunction explain poor survival?"
1/2015  - 12/2015 Research Fund Medical Research Centre, Cantonal Hospital St. Gallen Nr 14/17: "Activation of MERTK-signalling in monocytes/macrophages - a mechanism to explain susceptibility to infection in patients with cirrhosis and a future therapeutic target?"
10/2015  - 9/2019 Swiss National Science Foundation Project Grant 320030_159984: "Activation of MERTK-signalling in monocytes/macrophages - a mechanism to explain susceptibility to infection in patients with cirrhosis and a future therapeutic target?"
8/2019  - 7/2020 University of Basel, Research Fund Junior Researchers: “Assessment of circadian rhythm in non-alcoholic fatty liver disease”
1/2020  - 12/2023 Swiss National Science Foundation Project Grant 320030_189072 including Protected Research Time for Clinicians: “Diversity and compartmentalisation of monocytes & macrophages and immuneparesis in patients with cirrhosis”


Collaborations

National Collaborations

  • Prof. Dr. Markus Heim, University Centre for Gastrointestinal & Liver Diseases Basel and Hepatology Laboratory, Basel
  • Prof. Dr. Christian Cajochen, Centre for Chronobiology, University of Basel
  • PD Dr. Dr. David Semela, Gastroenterology & Hepatoloigy and Liver Biology Laboratory, St. Gallen
  • Prof. Dr. Burkhard Ludewig, Immunobiology, Medical Research Centre, St. Gallen
  • Prof. Dr. Dr. Annalisa Berzigotti, Hepatology, Inselspital Bern
  • Dr. Montserrat Fraga, Gastroenterology & Hepatologie, CHUV, Lausanne
  • PD Dr. Benedetta Terziroli, Epatocentro Ticino, University Ticino

International Collaborations

  • Prof. Dr. Julia Wendon & Dr. Mark McPhail, Institut of Liver Studies, King’s College London, UK
  • Prof. Dr. Mark Thursz and Dr. Evangelos Triantafyllou, Hepatology and Gastroenterology, Imperial College London, UK
  • Dr. Christopher Weston, Centre for Liver & Gastro Research, University of Birmingham, UK
  • Prof. Dr. Luigi Terracciano, Anatomic Pathology Unit, Humanitas University Research Hospital, Milano, Italy

Ongoing Research Projects

Activation of MERTK-signalling in monocytes/macrophages - a mechanism to explain susceptibility to infection in patients with cirrhosis and a future therapeutic target?
Assessment of circadian rhythm in non-alcoholic fatty liver disease
Diversity and compartmentalisation of monocytes & macrophages and immuneparesis in patients with cirrhosis

Clinical Multicentre Studies as local PI:

National:
- SASL 38 Swiss registry on Autoimmune Hepatitis (PI PD Dr. B. Terziroli, Ticino)
- SASL 39 Swiss registry on Primary Biliary Cholangitis (PI PD Dr. B. Terziroli, Ticino)
- SASL 40 Swiss registry on Primar Sclerosing Cholangitis SWISS PSC (PI PD Dr. B. Terziroli, Ticino)
- SASL 44 DAA Treatment Failure in Chronic Hepatitis C - The Swiss Experience (Dr. M. Fraga, Lausanne)

International:
- Pro-Euro-DILI Registry: Creation of a multicentre and multidisciplinary European registry of prospective drug-induced liver injury cases (PI: Prof. G. Aithal, University of Nottingham, UK)
- Investigation of Liver Involvement in Patients with alpha1-Antitrypsin Deficiency (PI: PD Dr. med. Pavel Strnad, University Hospital Aachen, Germany)
 


Research Team

Andrijana Bogdanovic

MD Student

Phone +41 61 556 55 03
Email

Anne Geng

PhD Student 

Phone +41 61 556 55 03
Email

Talitha Hildebrandt 

Master Student

Phone +41 61 556 55 03
Email

Robert Brenig, PhD

MD Student 

Phone +41 61 556 55 03
Email

Sylvia Pecenko

Research Assistant 

Phone +41 61 556 55 03
Email

Emilio Flint 

PhD Student 

Phone +41 61 556 55 03
Email

Sofia Roth, MD

Postdoc 

Phone +41 61 556 55 03
Email