Neurologie

Die Schwerpunkte der neurologischen Forschung liegen auf Multipler Sclerose (MS) und Hirnschlag. Die Datenzentren der jeweiligen nationalen Kohorte "MS Cohort Study" und des Registers "Swiss Stroke Registry" liegen beim DKF. Weitere Themengebiete sind die Erforschung von Macula- und Retinadegeneration, von Gliomas und diverse Fragestellungen in der Altersmedizin. In der pädiatrischen Neurologie widmen sich die Forschungsgruppen der Muskeldystrophie Duchenne, der Epilepsie, sowie der Multiplen Sclerose und Anorexia nervosa.



Auswahl aktueller Publikationen

Longitudinal Changes of Fixation Stability and Location within 24 Months in Stargardt Disease: ProgStar Report No. 16: Short title: Longitudinal Changes of Fixation in Stargardt Disease. Schönbach EM, Strauss RW, Cattaneo MEGV, Fujinami K, Birch DG, Cideciyan AV, Sunness JS, Zrenner E, Sadda SR, Scholl HPN; ProgStar Study Group. Am J Ophthalmol. 2021 Jul 20:S0002-9394(21)00380-9. doi: 10.1016/j.ajo.2021.07.013. Epub ahead of print. PMID: 34298008.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica. Tsagkas C, Schäfer S, Baumgartner A, Müller J, Sinnecker T, Mehling M, van der Stouwe JG, Felder S, Panagiotou A, Potlukova E, Winzeler B, Scholz MC, Timper K, Blackham K, Nickel CH, Christ-Crain M, Bingisser R, Lyrer P, Kappos L, Yaldizli Ö. Lancet. 2021 Jun 5;397(10290):2194. doi: 10.1016/S0140-6736(21)00986-7. PMID: 34090605.

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial. Kappos L, Fox RJ, Burcklen M, Freedman MS, Havrdová EK, Hennessy B, Hohlfeld R, Lublin F, Montalban X, Pozzilli C, Scherz T, D'Ambrosio D, Linscheid P,  Vaclavkova A, Pirozek-Lawniczek M, Kracker H, Sprenger T. JAMA Neurol. 2021 Mar 29 : e210405.J doi: 10.1001/jamaneurol.2021.0405 [Epub ahead of print]

Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: results from the BIOSIGNAL study. Arnold M, Schweizer J, Nakas CT, Schütz V, Westphal LP, Inauen C, Pokorny T, Luft A, Leichtle A, Arnold M, Bicvic A, Fischer U, De Marchis GM, Bonati LH, Müller MD, Kahles T, Nedeltchev K, Cereda CW, Kägi G, Bustamante A, Montaner J, Ntaios G, Foerch C, Spanaus K, von Eckardstein A, Katan M. Eur Heart J. 2021 Mar 8:ehab081. doi: 10.1093/eurheartj/ehab081. Epub ahead of print. PMID: 33709115.

Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sanchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben Assayag E, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Polymeris A, Wagner B, Seiffge DJ, Lyrer P, Algra A, Kappelle LJ, Al-Shahi Salman R, Jäger HR, Lip GYH, Fischer U, El-Koussy M, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Mess WH, Nederkoorn PJ, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra AC, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Hendrikse J, Kelly PJ, Wardlaw J, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Hara H, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network. Lancet Neurol. 2021 Apr;20(4):294-303. doi: 10.1016/S1474-4422(21)00024-7. Epub 2021 Mar 17. PMID: 33743239.

Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial. Engelter ST, Traenka C, Gensicke H, Schaedelin SA, Luft AR, Goeggel Simonetti B, Fischer U, Michel P, Sirimarco G, Kägi G, Vehoff J, Nedeltchev K, Kahles T, Kellert L, Rosenbaum S, von Rennenberg R, Sztajzel R, Leib SL, Jung S, Gralla J, Bruni N, Seiffge D, Feil K, Polymeris AA, Steiner L, Hamann J, Bonati LH, Brehm A, De Marchis GM, Peters N, Stippich C, Nolte CH, Christensen H, Wegener S, Psychogios MN, Arnold M, Lyrer P, on behalf of the TREAT-CAD investigators. Lancet Neurol. 2021 Mar 22; doi.org/10.1016/S1474-4422(21)00044-2

Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study. Hunziker S, Quinto A, Ramin-Wright M, Becker C, Beck K, Vincent A, Tisljar K, Disanto G, Benkert P, Leppert D, Pargger H, Marsch S, Raoul Sutter, Peters N, Kuhle J. Crit Care. 2021 Jan 20;25(1):32. doi: 10.1186/s13054-021-03459-y.

Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. Sutter R, Hert L, De Marchis GM, Twerenbold R, Kappos L, Naegelin Y, Kuster GM, Benkert P, Jost J, Maceski AM, Rüegg S, Siegemund M, Leppert D, Tschudin-Sutter S, Kuhle J.  Ann Neurol. 2020 Dec 30. doi: 10.1002/ana.26004. Epub ahead of print. PMID: 33377539.

Accuracy of calculated free valproate levels in adult patients with status epilepticus. Fisch U, Baumann SM, Semmlack S, Marsch S, Rüegg S, Sutter R. Neurology. 2020 Oct 14:10.1212/WNL.0000000000011000. doi: 10.1212/WNL.0000000000011000. Epub ahead of print. PMID: 33055270.

Serum neurofilament light in atrial fibrillation: clinical, neuroimaging and cognitive correlates. Alexandros A Polymeris, Michael Coslovksy, Stefanie Aeschbacher, Tim Sinnecker, Pascal Benkert, Richard Kobza, Jürg Beer, Nicolas Rodondi, Urs Fischer, Giorgio Moschovitis, Andreas U Monsch, Anne Springer, Matthias Schwenkglenks, Jens Wuerfel, Gian Marco De Marchis, Philippe A Lyrer, Michael Kühne, Stefan Osswald, David Conen, Jens Kuhle, Leo H Bonati, the SWISS-AF Investigators, , Brain Communications. 2020 October 06, fcaa166.

Ofatumumab versus Teriflunomide in Multiple Sclerosis. Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. PMID: 32757523

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis. Manouchehrinia A, Stridh P, Khademi M, Leppert D, Barro C, Michalak Z, Benkert P, Lycke J, Alfredsson L, Kappos L, Piehl F, Olsson T, Kuhle J, Kockum I.  Neurology. 2020 Jun 9;94(23):e2457-e2467. doi: 10.1212/WNL.0000000000009571. Epub 2020 May 20. PMID: 32434867.

Blood neurofilament light levels segregate treatment effects in multiple sclerosis. Delcoigne B, Manouchehrinia A, Barro C, Benkert P, Michalak Z, Kappos L, Leppert D, Tsai JA, Plavina T, Kieseier BC, Lycke J, Alfredsson L, Kockum I, Kuhle J, Olsson T, Piehl F. Neurology. 2020 Feb 11. pii:10.1212/WNL.0000000000009097. doi: 10.1212/WNL.0000000000009097. [Epub ahead of print]

Serum neurofilament light levels in normal aging and their association with morphologic brain changes. Khalil M, Pirpamer L, Hofer E, Voortman MM, Barro C, Leppert D, Benkert P, Ropele S, Enzinger C, Fazekas F, Schmidt R, Kuhle J. Nat Commun. 2020 Feb 10;11(1):812. doi: 10.1038/s41467-020-14612-6.

Artery occlusion independently predicts unfavorable outcome in cervical artery dissection. Traenka C, Grond-Ginsbach C, Goeggel Simonetti B, Metso TM, Debette S, Pezzini A, Kloss M, Majersik JJ, Southerland AM, Leys D, Baumgartner R, Caso V, Béjot Y, De Marchis GM, Fischer U, Polymeris A, Sarikaya H, Thijs V, Worrall BB, Bersano A, Brandt T, Gensicke H, Bonati LH, Touzeé E, Martin JJ, Chabriat H, Tatlisumak T, Arnold M, Engelter ST, Lyrer P; CADISP-Plus Study Group. Neurology. 2019 Nov 22. pii: 10.1212/WNL.0000000000008654. doi: 10.1212/WNL.0000000000008654. [Epub ahead of print]

Effect of Combination l-Citrulline and Metformin Treatment on Motor Function in Patients With Duchenne Muscular Dystrophy: A Randomized Clinical Trial. Hafner P, Bonati U, Klein A, Rubino D, Gocheva V, Schmidt S, Schroeder J, Bernert G, Laugel V, Steinlin M, Capone A, Gloor M, Bieri O, Hemkens LG, Speich B, Zumbrunn T, Gueven N, Fischer D. JAMA Netw Open. 2019 Oct 2;2(10):e1914171. doi: 10.1001/jamanetworkopen.2019.14171.

Emergency management of status epilepticus in a high-fidelity simulation: A prospective study. Sutter R, Tisljar K, Opić P, De Marchis GM, Bassetti S, Bingisser R, Hunziker S, Marsch S. Neurology. 2019 Oct 8. pii: 10.1212/WNL.0000000000008461. doi: 10.1212/WNL.0000000000008461. [Epub ahead of print]

Intravenous thrombolysis for suspected ischemic stroke with seizure at onset. Polymeris AA, Curtze S, Erdur H, Hametner C, Heldner MR, Groot AE, Zini A, Béjot Y, Dietrich A, Martinez-Majander N, von Rennenberg R, Gumbinger C, Schaedelin S, De Marchis GM, Thilemann S, Traenka C, Lyrer PA, Bonati LH, Wegener S, Ringleb PA, Tatlisumak T, Nolte CH, Scheitz JF, Arnold M, Strbian D, Nederkoorn PJ, Gensicke H, Engelter ST; TRISP Collaborators. Ann Neurol. 2019 Aug 21. doi: 10.1002/ana.25582. Epub ahead of print

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years. Cantó E, Barro C, Zhao C, Caillier SJ, Michalak Z, Bove R, Tomic D, Santaniello A, Häring DA, Hollenbach J, Henry RG, Cree BAC, Kappos L, Leppert D, Hauser SL, Benkert P, Oksenberg JR, Kuhle J. JAMA Neurol. 2019 Aug 12. doi: 10.1001/jamaneurol.2019.2137. [Epub ahead of print]

Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation. Seiffge DJ, Paciaroni M, Wilson D, Koga M, Macha K, Cappellari M, Schaedelin S, Shakeshaft C, Takagi M, Tsivgoulis G, Bonetti B, Kallmünzer B, Arihiro S, Alberti A, Polymeris AA, Ambler G, Yoshimura S, Venti M, Bonati LH, Muir KW, Yamagami H, Thilemann S, Altavilla R, Peters N, Inoue M, Bobinger T, Agnelli G, Brown MM, Sato S, Acciarresi M, Jager HR, Bovi P, Schwab S, Lyrer P, Caso V, Toyoda K, Werring DJ, Engelter ST, De Marchis GM; CROMIS-2, RAF, RAF-DOAC, SAMURAI, NOACISP LONGTERM, Erlangen and Verona registry collaborators. Ann Neurol. 2019 Jun;85(6):823-834. doi: 10.1002/ana.25489. Epub 2019 Apr 30.

Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data. Brott TG, Calvet D, Howard G, Gregson J, Algra A, Becquemin JP, de Borst GJ, Bulbulia R, Eckstein HH, Fraedrich G, Greving JP, Halliday A, Hendrikse J, Jansen O, Voeks JH, Ringleb PA, Mas JL, Brown MM, Bonati LH; Carotid Stenosis Trialists' Collaboration. Lancet Neurol. 2019 Apr;18(4):348-356. doi: 10.1016/S1474-4422(19)30028-6. Epub 2019 Feb 6.

A novel biomarker-based prognostic score in acute ischemic stroke: The CoRisk score. De Marchis GM, Dankowski T, König IR, Fladt J, Fluri F, Gensicke H, Foerch C, Findling O, Kurmann R, Fischer U, Luft A, Buhl D, Engelter ST, Lyrer PA, Christ-Crain M, Arnold M, Katan M. Neurology. 2019 Mar 26;92(13):e1517-e1525. doi: 10.1212/WNL.0000000000007177. Epub 2019 Mar 1.