Daiana Stolz

Prof. Daiana
Stolz, MD

Position(s)
Head physician, Clinic of Pneumology

Institution
University Hospital Basel

Phone +41 61 265 51 84

Email

 

Research Focus

Critical Care & Respiratory Medicine

Area of Research

  • Mechanisms involved in the pathophysiology of lung diseases, with focus on asthma and COPD
  • Evaluation and characterization of asthma and COPD progression and exacerbation
  • Assessment of prognostic markers allowing risk stratification in asthma and COPD
  • Identification of disease-specific cell-response pathways in order to improve therapeutic strategies and management of asthma and COPD
  • Elucidation of the mechanisms involved in responsiveness to inhaled corticosteroids in asthma and COPD

Approved Research Projects

  • Swiss National Foundation Grant - 5th Follow-up for SAPALDIA, Longitudinal Study Call 2017, SNF: SAPALDIA Cohort on Healthy Aging (co-applicant)
  • Kompetenznetz ambulant erworbene Pneumonie – CAPNETZ Studie, 2018. Clinical study, multicentric, international, investigator initiated and driven
  • FAILCAP study – Clinical failure and cardiovascular events in hospitalized patients with community-acquired pneumonia, 2010-2022. Clinical study, multicentric, international, investigator initiated and driven (co-investigator)
  • EMBARC - European Bronchiectasis Registry, 2015-ongoing. Clinical study, multicentric, international, investigator initiated and driven (co-investigator)
  • Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients, 2016-2018. Clinical study, monocentric, national, investigator initiated and driven
  • Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts, 2017-2018. Translational Study, multicentric, international, investigator initiated and driven
  • Multiplex bacterial polymerase chain reaction in a cohort of patients with pleural effusion, 2017-2019. Clinical study, monocentric, national, investigator initiated and driven
  • Clinical impact of multiplex bacterial PCR of bronchoalveolar lavage in patients with suspected LRTI, 2016-2019. Clinical study, monocentric, national, investigator initiated and driven
  • Does trumpet playing affect lung function? —A case-control study, 2018-2019. Clinical study, monocentric, national, investigator initiated and driven
  • The BioVent - BIOmarkers for mechanically VENTilated patients cohort study, 2013-2022. Clinical study, multicentric, international, investigator initiated and driven
  • SAPALDIA cohort on Healthy Aging, 2017-2021. Translational study, multicentric, national, investigator initiated and driven (co-PI)
  • Predictive value of oxygen desaturation during conscious sedation for flexible bronchoscopy regarding Obstructive Sleep Apnea – The PROSA-Study, 2019-2020. Clinical study, monocentric, national, investigator initiated and driven
  • Breath analysis using the Aeonose to diagnose acute pulmonary embolism, 2019-2021. Translational study, multicentric, national, investigator initiated and driven (co-investigator)
  • Integrated host gene expression diagnostic in suspected pneumonia and COPD exacerbation, 2019-ongoing. Translational study, monocentric, national, investigator initiated and driven
  • Nitrogen Washout versus Methacholin bronchoprovocation test for the diagnosis of bronchial asthma in patients with respiratory symptoms, 2019-ongoing. Clinical study, monocentric, national, investigator initiated and driven
  • Bronchial thermoplasty in asthma-COPD overlap syndrome (ACOS), 2017-2021. Translational study, multicentric, national, investigator initiated and driven
  • The ADORABLE study - The use of N2-washout for the early detection of bronchiolitis obliterans after allogeneic stem cell transplantation, 2016-ongoing. Translational study, monocentric, national, investigator initiated and driven
  • Respiratory Exacerbation Symptoms in COPD Undergoing Evaluation – The RESCUE study: Evaluating the usefulness of CT-scans in the diagnosis and management of COPD patients with exacerbations of respiratory symptoms. The RESCUE Study, 2020-ongoing. A randomised, interventional, controlled, non-inferiority study, multicentric, international, investigator-initiated and driven
  • Curbing High Risk of Non-obstructive smokers (the CHRONOS study) – an intervention study including the SAPALDIA cohort 2020-2023. Clinical study, monocentric, national, investigator initiated and driven
  • Swiss National Foundation Grant - The ratio of C/EBP-α to C/EBP-β controls airway wall remodeling in asthma through the regulation of microRNA-17-92 cluster, PRMT1 and mitochondria in airway smooth muscle cells“ 2017-2019 (co-applicant)
  • Histological, cellular and molecular investigation of steroid responsiveness in COPD – The Historic study 2017-2022, Astra-Zeneca AG, unrestricted grant
  • Fast Multiplex Assay of Gram-negative rods for antibiotic stewardship in hospitalized patients – The Flagship Study, 2017-2018, Curetis AG, unrestricted grant
  • Swiss National Foundation Grant - Towards precision medicine in COPD - Investigation of glucocorticoid responsiveness using primary airway cells from COPD patients 2019-2022
  • Member Research Team NFS (Nationaler Forschungsschwerpunkt) «NCCR-AntiResist: Neue Ansätze zur Bekämpfung Antibiotika-resistenter Bakterien», supported by the SNF, 2020-2023
  • Artificial Intelligence feasibility study for automated detection of sleep disorders, 2022. A study performed to determine the feasibility of a machine learning (ML) based approach for the automated analysis of polysomnography (PSG) data.
  • Preventing oxygen desaturation during bronchoscopy in patients with COPD comparing two oxygenation methods: PROSA II, 2021-ongoing. Evaluation of whether oxygen delivery using HFNO during sedation for bronchoscopy will improve oxygenation in patients with COPD compared to conventional oxygen by nasal cannula.
  • Quality control of antibiotic stewardship. FLAGSHIP IV, 2022-ongoing. Evaluation of whether a rapid multiplex PCR of BAL can decrease time on inappropriate antimicrobial therapy in patients with LRTI compared to conventional microbiological investigations alone.
  • Metagenomics in COPD and COPD exacerbations, 2021-ongoing. Metagenomic analysis in 3000 samples from sputum and nasopharengyal swabs
  • Metagenomics after allogeneic stem cell transplantation, 2021-ongoing. Metagenomic analysis in samples from 181 patients who underwent allogeneic stem cell transplantation

Collaborations

National Collaborations

  • University Hospital Basel, Dept. of Endocrinology, Diabetes and Metabolism (Prof. Donath and Prof. Christ-Crain)
  • University Hospital Basel, Emergency Department (Prof. Bingisser, Prof. Nickel)
  • University Hospital Basel, Dept. of Microbiology and Clinical Virology (Prof. Hirsch, Dr. Leuzinger)
  • University Hospital Basel, Dept. of Pathology (Prof. Bubendorf and Prof. Savic)
  • University Hospital Basel, Dept. of Infectious Diseases and Hospital Epidemiology (Prof. Khanna and Prof. Battegay)
  • University Hospital Basel, Dept. of Internal Medicine (Prof. Bassetti and Prof. Osthoff)
  • University Hospital Basel, Dept. of Hematology (Prof. Passweg, Prof. Halter)
  • University Hospital Basel, Dept. of Clinical Microbiology (Prof. Egli)
  • University Hospital Basel, Dept. of Research and Analytical Services (Dr. Stieltjes)
  • University Hospital Basel, Dept. of Cardiac and Thoracic Diagnostics (Prof. Bremerich)
  • Department of Biomedicine, Tumor Heterogeneity, Metastasis and Resistance (Prof. Bentires-Alj)
  • University Children’s Hospital Basel (Prof. Frey, Prof. Trachsler, Prof. Hammer)
  • University Hospital Lausanne CHUV (Prof. Eggimmann, Prof. Aubert)
  • University Hospital Zürich (Prof. Maggiorini, Dr. Graf, Prof. Kölzer, Dr. Nowak)
  • University Hospital Bern (Prof. Hilty)
  • Kanton Hospital Aarau, Switzerland (Prof. Müller, Prof. Schütz)
  • University Hospital Genf (Prof. Rochat)
  • Kanton Hospital St. Gallen (Prof. Brutsche, Prof. Albricht)

International Collaborations

  • University Hospital Paris (Prof. Chastre)
  • University Hospital Maastricht, The Netherlands (Prof. Wouters, Prof. Franssens)
  • Medizinische Hochschule Hannover, Germany (Prof. Welte)
  • University Hospital Clinic Barcelona, Spain (Prof. Torres)
  • University Hospital Badalona, Spain (Prof. Prat)
  • University Hospital Milano, Italy (Prof. Blasi, Prof. Aliberti)
  • University Hospital Liege, Belgium (Prof. Louis)
  • University of Ionannina Medical School, Greece (Assoc. Prof. Kostikas)
  • Medical Center Alkmaar, The Netherlands (Prof. Boersma)
  • Hospital Breda, The Netherlands (Dr. Aerts)
  • University Hospital Belgrade, Serbia (Prof. Milenkovic)
  • University Hospital Gent (Prof. Claus Bachert)
  • University of Campania “Luigi Vanvitelli”, Naples, Italy (Prof. Matera)
  • University of Rome "Tor Vergata", Italy (Prof Rogliani; Prof. Cazzola)
  • University Medical Center Groningen, The Netherlands (Prof. Gosens; Prof. van den Berge)
  • Manchester University NHS Foundation Trust, UK (Prof. Singh; Prof. Hanania; Prof. Vestbo)
  • Amsterdam University Medical Centers, The Netherlands (Prof. Maitland-van der Zee)
  • Sackler Institute of Pulmonary Pharmacology, King's College London, UK (Prof. Page)
  • Philips University Marburg, Germany (Prof. Renz, Prof. Schmeck)
  • University Medical Center Freiburg (Prof. Binder, Prof. Henneke, Prof. Ehl, Prof. Zeisser, Prof. Wengenmayer)
  • Friedrich-Alexander University Erlangen- Nürnberg (Prof. Ganslandt, Prof. Prokosch)
  • Goethe University Hospital Frankfurt (Prof. Rohde, Prof. Zielen, Prof. Bucher)
  • Justus Liebig University Gießen (Prof. Schneider, Prof. Kuhnert)
  • J. Gutenberg University Mainz (Prof. Buhl, Prof. Strauch)
  • University Medicine Charité (Prof. Lehmann, Prof. Elis)
  • Hannover Medical University (Prof. Dittrich, Prof. Hansen)
  • Ulm University (Prof. Kestler)
  • Saarland University (Prof. Bals, Prof. Wagenpfeil)
  • University Essen (Prof. Taube, Prof. Nensa)
  • University of Hamburg (Prof. Ückert)

Ongoing Research Projects

  • BASel cohort of patients undergoing bronchoscopy on COPD  – BASCO Study. 2006-ongoing. Clinical study, monocentric, national, investigator initiated and driven. 460 patients have already been included.
  • Immunocommpromised patients with suspicion of LRTI undergoing bronchoscopy – the ImmunSup cohort Study. 2008-on-going. Clinical study, multicentric, national, investigator initiated and driven. 3261 patients have already been included
  • EMBARC - European Bronchiectasis Registry. 2015-ongoing. Clinical study, multicentric, international, investigator initiated and driven. 75 patients have already been included.
  • Preventing oxygen desaturation during bronchoscopy in patients with COPD comparing two oxygenation methods: PROSA II. 2021-ongoing. Evaluation of whether oxygen delivery using HFNO during sedation for bronchoscopy will improve oxygenation in patients with COPD compared to conventional oxygen by nasal cannula.
  • Quality control of antibiotic stewardship. FLAGSHIP IV. 2022-ongoing. Evaluation of whether a rapid multiplex PCR of BAL can decrease time on inappropriate antimicrobial therapy in patients with LRTI compared to conventional microbiological investigations alone.
  • Metagenomics in COPD and COPD exacerbations. 2021-ongoing. Metagenomic analysis in 3000 samples from sputum and nasopharengyal swabs.
  • Metagenomics after allogeneic stem cell transplantation. 2021-ongoing. Metagenomic analysis in samples from 181 patients who underwent allogeneic stem cell transplantation
  • The ADORABLE study - The use of N2-washout for the early detection of bronchiolitis obliterans after allogeneic stem cell transplantation. Translational study, monocentric, national, investigator initiated and driven. Sponsor: UHB. Implementing Institution: UHB unrestricted grant. 181 patients. 2016-2022
  • The BioVent - BIOmarkers for mechanically VENTilated patients cohort study. Clinical study, multicentric, international, investigator initiated and driven. Clinical study, multicentric, international, investigator initiated and driven. Sponsor: UHB. Implementing Institution: UHB. 1000 patients. 2013-2022
  • The HISTORIC study - Histological, cellular and molecular Investigation of Steroid Responsiveness in chronic obstructive pulmonary disease. Translational study, monocentric, national, investigator initiated and driven. Sponsor: UHB. Implementing Institution: UHB unrestricted grant. 188 patients. 2017-2022
  • Respiratory Exacerbation Symptoms in COPD Undergoing Evaluation – The RESCUE study: Evaluating the usefulness of CT-scans in the diagnosis and management of COPD patients with exacerbations of respiratory symptoms. A randomised, interventional, controlled, non-inferiority study - The RESCUE Study. Sponsor: UHB. Implementing Institution: UHB. 18 patients. 2020-2022
  • Integrated host gene expression diagnostic in suspected pneumonia and COPD exacerbation. Τranslational study, monocentric, national, investigator initiated and driven. Sponsor: UHB. Implementing Institution: UHB. 669 patients. 2019-2022
  • Nitrogen Washout versus Methacholin bronchoprovocation test for the diagnosis of bronchial asthma in patients with respiratory symptoms. Clinical study, monocentric, national, investigator initiated and driven. Sponsor: UHB. Implementing Institution: UHB unrestricted grant. 106 patients. 2019-2022
  • Towards precision medicine in COPD-Investigation of glucocorticoid responsiveness using primary airway cells from COPD patients. SNF 2019-2022
  • Curbing High Risk of Non-obstructive smokers (the CHRONOS study) – an intervention study including the SAPALDIA cohort 2020-2023

 


Research Team

Prof. Michael Tamm, MD

Research Fellow

Phone +41 61 328 61 85
Email

Werner Strobel, MD

Research Fellow

Phone +41 61 328 69 22
Email

Kathleen Jahn, MD

Research Fellow

Phone +41 61 556 57 36
Email

Aline Stalder-Siebeneichler, MD

Research Fellow

Phone +41 61 328 50 73
Email

Maria Pascarella

Study Nurse

Phone +41 61 328 55 13
Email

Eleni Papakonstantinou, MD

Research Fellow

Phone +41 61 328 68 98
Email

Prof. Michael Roth, PhD

Research Fellow

Phone +41 61 328 67 85
Email

Lucas Böck, MD

Research Fellow

Phone +41 61 328 69 27
Email

Jonathan Roecken, MD

Research Fellow

Phone +41 61 328 50 74
Email

Nora Oertli

Study Nurse

Phone +41 61 328 63 39
Email

Leticia Grize, PhD

Research Fellow

Phone +41 61 328 68 98
Email

Matthias Herrmann, MD

Research Fellow

Phone +41 61 328 55 15
Email

Andrei Darie, MD

Research Fellow

Phone +41 61 328 69 26
Email

Lei Fang, PhD

Research Fellow

Phone +41 61 265 23 91
Email