Özgür Yaldizli

PD Özgür Yaldizli, MD

Position(s)
Senior Physician Neurology

Institution
University Hospital Basel

Phone
+41 61 556 55 54

Email

Research Focus

Neurology

Area of Research

The goal of my research is to understand the mechanisms underlying disease progression in multiple sclerosis and to investigate the effect of multiple sclerosis disease modifying treatment. To answer these questions, we use data from two large databases, the Swiss Multiple Sclerosis Treatment Registry governed by the Swiss association for joint tasks of health insurers and the Swiss Multiple Sclerosis Cohort Study, the largest multicenter observational study on multiple sclerosis and related neuroinflammatory diseases in Switzerland. 


Approved Research Projects

  • Comparative analysis of Dimethyl Fumarate and Teriflunomide in relapsing remitting multiple sclerosis 
  • Deep learning to harmonize the MRI contrast over a scanner change in a longitudinal multiple sclerosis cohort study
  • Balance during stance and gait: Clinical relevance for multiple sclerosis patients.
  • The effect of 2 weeks of vibrotactile biofeedback of trunk sway on balance control in multiple sclerosis: a pilot study 
  • The dynamics of cortical grey matter lesion and non-lesional abnormalities, and their clinical relevance in multiple sclerosis: a serial magnetic resonance imaging study.

Collaborations

National Collaborations

Kantonsspital Aarau (Dr Lutz Achtnichts)
University of Berne (Prof Andrew Chan)
University of Geneva (Prof Patrice Lalive)
CHUV (Prof Caroline Pot, Prof Renaud Du Pasquier)
CEO (Prof Claudio Gobbi, Dr Chiara Zecca)
Kantonsspital St. Gallen (Dr Stefanie Müller)
Department of Biomedical Engineering (Prof. C. Granziera, Basel)
Medical Image Analysis Centre Basel (Dr. J. Wuerfel)
University of Zurich (Dr Viktor von Wyl)

International Collaborations

Charite, Berlin (Prof Friedemann Paul)
Kyushu University Hospital (Prof Watanabe, Dr Shoko Fukumoto)
University College London (Dr Declan Chard, Dr Rosa Cortese)
Universita di Genova (Dr Matteo Pardini)


Ongoing Research Projects

  • Brain MRI T1 weighted gray matter/ normal appearing white matter contrast to differentiate multiple sclerosis from migraine
  • Brain atrophy measurement over a scanner change in a large multiple sclerosis cohort
  • Diffusion mri to predict progression independent of relapses in relapsing-remitting multiple sclerosis patients
  • Brain Choroid Plexus is larger in Multiple Sclerosis than Neuromyelitis Optica Spectrum Disorder
  • Interrupting disease modifying treatment for pregnancy in multiple sclerosis – effect on disease activity and serum neurofilament light chain
  • Value of serum neurofilament light chain levels as a biomarker of suboptimal treatment response in MS clinical practice
  • Comparative analysis of Dimethyl Fumarate and Teriflunomide in relapsing remitting multiple sclerosis
  • Association between serum NfL and cognitive deficits in multiple sclerosis

Research Team

Jannis Müller

Research Fellow

Phone +41 61 328 67 62 
Email

Vera Canova

Research Fellow

Phone   -  
Email

Gizem Tan

Research Fellow

Phone   -  
Email

Dr. med. Tim Sinnecker

Research Fellow

Phone +41 61 328 7520 
Email

Tina Mitrovic

Research Fellow

Phone +41 61 328 45 38 
Email

Prof. John Allum, PhD

Consultant

Phone +41 61 265 20 41 
Email 

Laurent Baumann

Research Fellow

Phone   -
Email

Sophia Reimann

Research Fellow

Phone  -  
Email