The clinical research groups in this focal area are dedicated to a broad spectrum of disease patterns. On the one hand, the research efforts are focussing on diabetes, obesity, diseases of the pituitary gland, thyroid gland, adrenal glands and bone, on the other hand on reproductive endocrinology and congenital developmental disorders as well as pregnancy complications.

Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial. Lüthi H, Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, Steinmetz M, Bathelt C, Sailer CO, Laager M, Vogt DR, Hemkens LG, Speich B, Urwyler SA, Kühne J, Baur F, Lutz LN, Erlanger TE, Christ-Crain M, Winzeler B. EClinicalMedicine. 2024 Feb 9;68:102429. doi: 10.1016/j.eclinm.2024.102429. PMID: 38371479; PMCID: PMC10873660.

Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trial. Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, Steinmetz M, Bathelt C, Sailer CO, Vogt DR, Hemkens LG, Speich B, Urwyler SA, Kühne J, Baur F, Lutz LN, Erlanger TE, Christ-Crain M, Winzeler B. EClinicalMedicine. 2023 Feb 21. Epub ahead of print.

Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. Refardt J, Imber C, Nobbenhuis R, Sailer CO, Haslbauer A, Monnerat S, Bathelt C, Vogt DR, Berres M, Winzeler B, Bridenbaugh SA, Christ-Crain M. J Am Soc Nephrol. 2022 Nov 17:ASN.2022050623. doi: 10.1681/ASN.2022050623. Epub ahead of print. PMID: 36396331.

Canakinumab in patients with COVID-19 and type 2 diabetes - A multicentre, randomised, double-blind, placebo-controlled trial. Hepprich M, Mudry JM, Gregoriano C, Jornayvaz FR, Carballo S, Wojtusciszyn A, Bart PA, Chiche JD, Fischli S, Baumgartner T, Cavelti-Weder C, Braun DL, Günthard HF, Beuschlein F, Conen A, West E, Isenring E, Zechmann S, Bucklar G, Aubry Y, Dey L, Müller B, Hunziker P, Schütz P, Cattaneo M, Donath MY. EClinicalMedicine. 2022 Sep 17;53:101649.

Association of Interprofessional Discharge Planning Using an Electronic Health Record Tool With Hospital Length of Stay Among Patients with Multimorbidity: A Nonrandomized Controlled Trial. Kutz A, Koch D, Haubitz S, Conca A, Baechli C, Regez K, Gregoriano C, Ebrahimi F, Bassetti S, Eckstein J, Beer J, Egloff M, Kaeppeli A, Ehmann T, Hoess C, Schaad H, Wharam JF, Lieberherr A, Wagner U, de Geest S, Schuetz P, Mueller B. JAMA Netw Open. 2022 Sep 1;5(9):e2233667. doi: 10.1001/jamanetworkopen.2022.33667. PMID: 36169957; PMCID: PMC9520366.

Central diabetes insipidus from a patient's perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey. Atila C, Loughrey PB, Garrahy A, Winzeler B, Refardt J, Gildroy P, Hamza M, Pal A, Verbalis JG, Thompson CJ, Hemkens LG, Hunter SJ, Sherlock M, Levy MJ, Karavitaki N, Newell-Price J, Wass JAH, Christ-Crain M. Lancet Diabetes Endocrinol. 2022 Aug 22:S2213-8587(22)00219-4. doi: 10.1016/S2213-8587(22)00219-4. Epub ahead of print. PMID: 36007536.

Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind, randomized, placebo-controlled study. Atila C, Gaisl O, Vogt DR, Werlen L, Szinnai G, Christ-Crain M. Eur J Endocrinol. 2022 May 12;187(1):65-74. doi: 10.1530/EJE-22-0033. PMID: 35521789.

The cephalic phase of insulin release is modulated by IL-1β. Wiedemann SJ, Trimigliozzi K, Dror E, Meier DT, Molina-Tijeras JA, Rachid L, Le Foll C, Magnan C, Schulze F, Stawiski M, Häuselmann SP, Méreau H, Böni-Schnetzler M, Donath MY. Cell Metab. 2022 Jul 5;34(7):991-1003.e6. Epub 2022 Jun 23.

Inflammation in obesity, diabetes, and related disorders. Rohm TV, Meier DT, Olefsky JM, Donath MY. Immunity. 2022 Jan 11;55(1):31-55. doi: 10.1016/j.immuni.2021.12.013. PMID: 35021057; PMCID: PMC8773457.

A randomized controlled trial of GLP-1 receptor agonist dulaglutide in primary polydipsia. Winzeler B, Sailer CO, Coynel D, Zanchi D, Vogt DR, Urwyler SA, Refardt J, Christ-Crain M. J Clin Invest. 2021 Sep 2:151800. doi: 10.1172/JCI151800. Epub ahead of print. PMID: 34473645.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica. Tsagkas C, Schäfer S, Baumgartner A, Müller J, Sinnecker T, Mehling M, van der Stouwe JG, Felder S, Panagiotou A, Potlukova E, Winzeler B, Scholz MC, Timper K, Blackham K, Nickel CH, Christ-Crain M, Bingisser R, Lyrer P, Kappos L, Yaldizli Ö. Lancet. 2021 Jun 5;397(10290):2194. doi: 10.1016/S0140-6736(21)00986-7. PMID: 34090605.

Individualized Nutritional Support for Hospitalized Patients With Chronic Heart Failure. Hersberger L, Dietz A, Bürgler H, Bargetzi A, Bargetzi L, Kägi-Braun N, Tribolet P, Gomes F, Hoess C, Pavlicek V, Bilz S, Sigrist S, Brändle M, Henzen C, Thomann R, Rutishauser J, Aujesky D, Rodondi N, Donzé J, Stanga Z, Mueller B, Schuetz P. J Am Coll Cardiol. 2021 May 11;77(18):2307-2319.

Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in Children. Burckhardt MA, Gotta V, Beglinger S, Renggli L, Bachmann S, Hess M, Rentsch K, Pfister M, Koch G, Davis EA, Zumsteg U, Jones TW, Szinnai G.  J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa568. doi: 10.1210/clinem/dgaa568. PMID: 32835363.

Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β. Hepprich M, Wiedemann SJ, Schelker BL, Trinh B, Stärkle A, Geigges M, Löliger J, Böni-Schnetzler M, Rudofsky G, Donath MY. Cell Metab. 2020 Mar 12. pii: S1550-4131(20)30072-3. doi: 10.1016/j.cmet.2020.02.013. [Epub ahead of print]

A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate Antidiuresis. Refardt J, Imber C, Sailer CO, Jeanloz N, Potasso L, Kutz A, Widmer A, Urwyler SA, Ebrahimi F, Vogt DR, Winzeler B, Christ-Crain M. J Am Soc Nephrol. 2020 Feb 4. pii: ASN.2019090944. doi: 10.1681/ASN.2019090944. [Epub ahead of print]

Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study. Winzeler B, Cesana-Nigro N, Refardt J, Vogt DR, Imber C, Morin B, Popovic M, Steinmetz M, Sailer CO, Szinnai G, Chifu I, Fassnacht M, Christ-Crain M. The Lancet. 2019 Aug 17;394(10198):587-595. doi: 10.1016/S0140-6736(19)31255-3. Epub 2019 Jul 11.

Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial. Schuetz P, Fehr R, Baechli V, Geiser M, Deiss M, Gomes F, Kutz A, Tribolet P, Bregenzer T, Braun N, Hoess C, Pavlicek V, Schmid S, Bilz S, Sigrist S, Brändle M, Benz C, Henzen C, Mattmann S, Thomann R, Brand C, Rutishauser J, Aujesky D, Rodondi N, Donzé J, Stanga Z, Mueller B. The Lancet. 2019 Jun 8;393(10188):2312-2321. doi: 10.1016/S0140-6736(18)32776-4. Epub 2019 Apr 25

Association Between Glycemic Control and Risk of Fracture in Diabetic Patients: A Nested Case-Control Study. Vavanikunnel J, Charlier S, Becker C, Schneider C, Jick SS, Meier CR, Meier C. J Clin Endocrinol Metab. 2019 May 1;104(5):1645-1654. doi: 10.1210/jc.2018-01879.

Exome sequencing of fetal anomaly syndromes: novel phenotype-genotype discoveries. Meier N, Bruder E, Lapaire O, Hoesli I, Kang A, Hench J, Hoeller S, De Geyter J, Miny P, Heinimann K, Chaoui R, Tercanli S, Filges I. Eur J Hum Genet. 2019 May;27(5):730-737. doi: 10.1038/s41431-018-0324-y. Epub 2019 Jan 24.

Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans. Maushart CI, Loeliger R, Gashi G, Christ-Crain M, Betz MJ. Thyroid. 2019 Apr;29(4):493-501. doi: 10.1089/thy.2018.0436. Epub 2019 Mar 8.

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. Fenske W, Refardt J, Chifu I, Schnyder I, Winzeler B, Drummond J, Ribeiro-Oliveira A Jr, Drescher T, Bilz S, Vogt DR, Malzahn U, Kroiss M, Christ E, Henzen C, Fischli S, Tönjes A, Mueller B, Schopohl J, Flitsch J, Brabant G, Fassnacht M, Christ-Crain M. N Engl J Med. 2018 Aug 2;379(5):428-439. doi: 10.1056/NEJMoa1803760.