Research Focus

Neurology

Area of Research

Clinical stroke research. Carotid and vertebral artery dissection. Genetics in stroke. Thrombolysis and thrombectomy (coagulation inhibition) in acute stroke, evidence-based therapy. Non-vitamin K antagonists and stroke, cerebral hemorrhage, stroke in the elderly, neurorehabilitation after stroke

• TREAT-CAD (PI) “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD), Co-applicant
• ESTREL( local PI) “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”, Co-applicant
• TICH-NOAC (Co-Chair) Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist (TICH-NOAC), Sponsor Investigator
• TELESTROKE (Chair) Telemedical onsite identification of stroke victims: Stiftung propatient USB, Principal Investigator
• Metabolic Mechanisms of cerebral small vessel disease, Lab Project, Principal Investigator
• MAAESTRO “Electronic monitoring and improvement of adherence to direct oral anticoagulant treatment – a randomised crossover study of an educational and reminderbased intervention in ischaemic stroke patients under polypharmacy, Principal Investigator

Investigator-initiated Research Initiatives (European Research Consortia)

• Cervical Artery Dissection in Ischemic Stroke Patients (CADISP), Founding member, Investigator
• Thrombolysis in Ischemic Stroke Patients (TRISP), Investigator
• Novel Oral AntiCoagulants in Stroke Patients (NOACISP), Sponsor Investigator

National Collaborations
- TICH-NOAC (planned to be extended to GB and DK)
- ESTREL

International Collaborations
- ECST-2
- CADISP (Cervical artery dissection in stroke patients)
- GLORIA – AF (submitted database analysis and publications)

• TICH-NOAC: Treatment of cerebral haemorrhage due to NOAC-intake with tranexamid acid, a RCT: accomplishing the goal 109 randomized patients
• “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)”
• Databank cleaning, adjudication of outcome events “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD)
• “New Oral Anticoagulants in Stroke Patients” (NOACISP) – acute register and follow –up, completion of follow-up for 1000 patients
• TELESTROKE: expansion to clinical application
• ECST-2 The 2nd European Carotid Surgery Trial, sub-Investigator, Steering Committee Member, Adjudicator
• OPTIMIZE: Prospective non-interventional study for the optimized treatment of refractory hypercholesterolemia in patients with heterozygous familial hypercholesterolemia or clinically apparent atherosclerotic cardiovascular disease with alirocumab (Praluent®)
• ACTIMIS: randomized, double blind, multicenter, multinational, placebo controlled, single parallel escalating dose safety and efficacy study of act017 used as an add-on therapy on top of standard of care, in the 4.5 hrs post onset of acute ischemic stroke symptoms.
• Administrative and regulatory support of research projects for members of the stroke team (Twist, TRISP, ACST2, Precise-MRI, ELAN)