KIDS-STEP - a study on corticosteroid therapy in children with severe pneumonia
In adults with pneumonia, the administration of corticosteroids leads to faster stabilisation and faster discharge from hospital. Does this also apply to children?
The available study results on the administration of corticosteroids in hospitalized adults with pneumonia give reason to hope that a similar effect exists for children.
It is not possible to assess at present whether in children a faster recovery under corticosteroids could be associated with an increased risk of recurrence of pneumonia. Although it is highly unlikely, there is a possibility that such a phenomenon outweighs the positive effect of corticosteroids in the acute phase.
This large-scale international multicentre clinical trial investigates the influence of corticosteroids on disease stabilisation during hospitalisation and on the recurrence of symptoms in children hospitalised with pneumonia.
Betamethasone Therapy in Hospitalised Children With Community-aquired Pneumonia (CAP)
Prof. Johannes van den Anker and Dr. Julia Bielicki, University Children's Hospital Basel
8 centres in Switzerland
4 centres in Germany
Methodological Consulting, Statistics, Regulatory Affairs, Data Management, Monitoring
KIDS-STEP study website
Do corticosteroids have a positive effect on the recovery of children with severe penumonia?
Randomized, placebo-controlled, blinded, multicenter superiority study with 2 comparably poor
Importance of the study
A positive effect of corticosteroids on the recovery of children with pneumonia could lead to shorter hospitalisation.
September 2020, Update February 2023