/ JCEM
Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in Children.
Burckhardt MA, Gotta V, Beglinger S, Renggli L, Bachmann S, Hess M, Rentsch K, Pfister M, Koch G, Davis EA, Zumsteg U, Jones TW, Szinnai G.
J Clin Endocrinol Metab. 2020 Nov 1;105(11)
dgaa568. doi: 10.1210/clinem/dgaa568. PMID: 32835363.
In this multicenter prospective observational study, the DKF research group led by PD Dr. Gabor Szinnai (Endocrinology, Diabetology & Metabolism/UKBB) characterizes for the first time Copeptin kinetics and dynamics in the high hyperosmolar range in children with diabetic ketoacidosis. In addition, significant differences in Copeptin kinetics between newly diagnosed and known type 1 diabetes patients were shown, which can be explained by changes in osmoreceptors and renal arginine vasopressin receptors as a result of long-term osmotic diuresis and diabetic ketoacidosis.