/ Neurology
Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.
Manouchehrinia A, Stridh P, Khademi M, Leppert D, Barro C, Michalak Z, Benkert P, Lycke J, Alfredsson L, Kappos L, Piehl F, Olsson T, Kuhle J, Kockum I.
Neurology. 2020 Jun 9;94(23):e2457-e2467.
doi: 10.1212/WNL.0000000000009571. Epub 2020 May 20. PMID: 32434867.
This study lead by the DKF research group of Prof. Jens Kuhle (Neurology/USB) investigates the relationship between concentrations of neurofilament light chains in plasma (pNfL) and multiple sclerosis (MS). The work was carried out in cooperation with researchers from Karolinska University Hospital in Stockholm and the DKF. It was shown that increased pNfL levels in early stages of MS are associated with an increased risk of permanent physical disability. NfL has become known primarily for the specific degradation of nerve cells. This and other studies show that pNfL could serve as a predictive tool to assess the risk of long-term disability in MS.