/ Cell Metabolism
Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β
Hepprich M, Wiedemann SJ, Schelker BL, Trinh B, Stärkle A, Geigges M, Löliger J, Böni-Schnetzler M, Rudofsky G, Donath MY.
Cell Metabolism, 2020 Mar 12.
pii: S1550-4131(20)30072-3. doi: 10.1016/j.cmet.2020.02.013. [Epub ahead of print]
After a gastric bypass operation, recurrent hypoglycaemia can occur after every meal as a serious complication. In a study led by DKF Clinical Research Group Leader Prof. Marc Donath (Endocrinology, Diabetology & Metabolism/USB), the mechanism of hypoglycaemia was investigated and the use of the SGLT2 inhibitor empagliflozine and the IL-1 receptor antagonist anakinra was successfully tested. The results were recently published in the journal Cell Metabolism.