Successful recruitment of study participants
Inadequate recruitment is the most common reason for premature termination of randomised clinical trials (RCTs). This is particularly true for academic trials initiated by sponsor-investigators .
The reasons for recruitment failure in RCTs are multiple and often interrelated [2,3]. Many causes are considered preventable and therefore should be appropriately considered when planning clinical trials .
Below table summarises the 10 most common causes of inadequate recruitment  and suggests measures to address them in order to reduce the risk of missing recruitment goals. Here you can download the table as a pdf.
Reasons for insufficient recruitment and what can be done about it:
|2. Inclusion/exclusion criteria are defined too narrowly|
3. Recruitment is not coordinated well enough with routine procedures in the clinic
|5. Commitment/collaboration in the study team is lacking|
6. Identification with the research question is insufficient (equipoise)
|7. Initial funding is insufficient|
|8. Other studies recruit the same patient population or require the same resources|
|9. Study design is too complex to explain and to implement|
10. Methodological and logistical support is lacking