/ Vaccine
Dose-dependent effectiveness of acellular pertussis vaccine in infants: A population-based case-control study
Mack I, Erlanger TE, Lang P, Sinniger P, Perisa D, Heininger U.
Vaccine.
2020 Feb 5;38(6):1444-1449. doi: 10.1016/j.vaccine.2019.11.069. Epub 2019 Dec 5.
The effectiveness of the pertussis vaccination has been controversially discussed in recent years. Due to the increased incidence of pertussis cases, there has been speculation whether the effectiveness of this childhood vaccination may have decreased.
Under the direction of Prof. Ulrich Heininger (Infectiology, Vaccinology/UKBB), Dr. Ines Mack (Infectiology, UKBB), in cooperation with the DKF, the University of Zurich and the Federal Office of Public Health, has published a vaccine efficacy study with data from Switzerland in the journal "Vaccine". Concerns that the acellular vaccine might have lost its efficacy have not been confirmed. After four doses administered, the vaccine prevents practically 100% of the pertussis cases that require hospitalization.