Clinical Pharmacology

The topics of this focus are broadly diversified and range from pharmacokinetics in special patient populations to the effects of psychoactive substances and pharmaceutical thechnology research. Two research groups are also dedicated to various pharmacological questions in paediatrics.

Selected current publications

Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland. Thoueille P, Saldanha SA, Schaller F, Choong E, Munting A, Cavassini M, Braun D, Günthard HF, Kusejko K, Surial B, Furrer H, Rauch A, Rougemont M, Ustero P, Calmy A, Stöckle M, Marzolini C, Di Benedetto C, Bernasconi E, Schmid P, Piso RJ, Andre P, Girardin FR, Guidi M, Buclin T, Decosterd LA; Swiss HIV Cohort Study. Lancet Reg Health Eur. 2023 Dec 13;36:100793. doi: 10.1016/j.lanepe.2023.100793. PMID: 38162253; PMCID: PMC10757247.

Antiretroviral drug exposure and response in obese and morbidly obese people with HIV: a study combining modelling and Swiss HIV Cohort data; Berton M, Bettonte S, Stader F, Decosterd L, Tarr PE, Livio F, Cavassini M, Braun DL, Kusejko K, Hachfeld A, Bernasconi E, Calmy A, Schmid P, Battegay MMarzolini C.; Clin Infect Dis. 2023 Aug 21:ciad495. Epub ahead of print.

Leukocyte Count and Coronary Artery Disease Events in People with HIV: A Longitudinal Study. Avery EF, Kleynhans JN, Ledergerber B, Schoepf IC, Thorball CW, Kootstra NA, Reiss P, Ryom L, Braun DL, Thurnheer MC, Marzolini C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos RD, Fellay J, Günthard HF, Tarr PE; Swiss HIV Cohort Study. Clin Infect Dis. 2023 Jan 23:ciad033. doi: 10.1093/cid/ciad033. Epub ahead of print. PMID: 36688465.

Management of drug-drug interactions between long-acting cabotegravir and rilpivirine and comedications with inducing properties: a modelling study. Bettonte S, Berton M, Stader F, Battegay M, Marzolini C. Clin Infect Dis. 2022 Nov 15:ciac901. doi: 10.1093/cid/ciac901. Epub ahead of print. PMID: 36377436.

Prescribing Nirmatrelvir-Ritonavir: How to Recognize and Manage Drug-Drug Interactions. Marzolini C, Kuritzkes DR, Marra F, Boyle A, Gibbons S, Flexner C, Pozniak A, Boffito M, Waters L, Burger D, Back D, Khoo S. Ann Intern Med. 2022 Mar 1. Epub ahead of print.

Fluvoxamine for the treatment of COVID-19. Lancet Glob Health. Marzolini C, Marra F, Boyle A, Khoo S, Back DJ. Lancet Glob Health. 2022 Mar;10(3):e331.

Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE; Swiss HIV Cohort Study. Clin Infect Dis. 2021 Nov 2;73(9):1597-1604.

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial Bielicki JA, Stöhr W, Barratt S, Dunn D, Naufal N, Roland D, Sturgeon K, Finn A, Rodriguez-Ruiz JP, Malhotra-Kumar S, Powell C, Faust SN, Alcock AE, Hall D, Robinson G, Hawcutt DB, Lyttle MD, Gibb DM, Sharland M; PERUKI, GAPRUKI, and the CAP-IT Trial Group. JAMA. 2021 Nov 2;326(17):1713-1724.

Coronary Artery Disease-associated and Longevity-associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living with HIV: The Swiss HIV Cohort Study. Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE; , for the Swiss HIV Cohort Study. Clin Infect Dis. 2021 Jun 6:ciab521. doi: 10.1093/cid/ciab521. Epub ahead of print. PMID: 34091660.