Research Focus

Neurology

Area of Research

Clinical Stroke Research. Carotid and vertebral artery dissection. Stroke genetics. Thrombolysis and thrombectomy in acute stroke. Evidence-based therapy. Non-vitamin K antagonists and stroke, cerebral hemorrhage. Stroke in the elderly, neurorehabilitation after stroke.

RCTs.

• TREAT-CAD (PI) “Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD) (https://clinicaltrials.gov/ct2/show/NCT02046460)
• ESTREL (PI) “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)” (https://clinicaltrials.gov/ct2/show/NCT03735901)
• TWIST (national coordinator Switzerland) Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) https://clinicaltrials.gov/ct2/show/NCT03181360
• TICH-NOAC (Co-Chair) Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist (TICH-NOAC) (https://clinicaltrials.gov/ct2/show/NCT02866838)

Investigator-initiated Research Initiatives (European Research Consortia): 

• Cervical Artery Dissection in Ischemic Stroke Patients (CADISP): Founding member; Member of Scientific Committee
• Thrombolysis in Ischemic Stroke Patients (TRISP): Initiator; Lead coordinator
• Novel Oral AntiCoagulants in Stroke Patients (NOACISP): Initiator (https://clinicaltrials.gov/ct2/show/NCT03826927)

National Collaborations
- ESTREL

International Collaborations
- TRISP
- CADISP (Cervical artery dissection in stroke patients)
- TREAT-CAD
- ESTREL

• “Enhancement of Stroke Rehabilitation With Levodopa (ESTREL)” (https://clinicaltrials.gov/ct2/show/NCT03735901)
• Databank cleaning, adjudication of outcome events “ Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection“ (TREAT-CAD) (https://clinicaltrials.gov/ct2/show/NCT02046460) 
• “New Oral Anticoagulants in Stroke Patients” (NOACISP) – a registry with a focus on very aged or multimorbid patients (https://clinicaltrials.gov/ct2/show/NCT03826927)