Research Focus

Regenerative Medicine & Biomechanics

Area of Research

A. Spine biomechanics
B. Spinal Tumors
C. Interdisciplinary treatment concepts for multifactorial spinal disorders

Ongoing

• CSS – Assessing The Course Of Degenerative Cervical Spine Stenosis Using Functional Outcomes (Id 2019-01270)
• RoLSSroice - Role of spinal load in the pathophysiology of lumbar spinal stenosis: a translational approach combining clinical, functional and radiological parameters, in vivo biomechanical experiments and advanced in silico musculoskeletal modeling (Swiss National Science Foundation)
• MTRON - Metastatic Tumor Research And Outcomes Network Register Study (Id 2018-00129)
• Atrophylss - Association Between Lumbar Muscle Atrophy, Sagittal Pelvic Alignment And Stenosis Grade In Patients With Degenerative Lumbar Spinal Stenosis (Id 2020-00150)
• Musclss - Effect Of Muscle Fatigue On Spinal Imbalance And Motion In Lumbar Spinal Stenosis: Single Center Observational Pilot Study (Id 2021-02012)

Finished

• Preclinical evaluation of disease modifying drugs in a novel ex vivo human spine osteoarthritis explant model (Gottfried and Julia Bangerter-Rhyner Foundation)
• Targeting the perturbed bone marrow niche and pathological bone remodelling in human  osteoarthritis” (Gottfried and Julia Bangerter-Rhyner Foundation)
• LIQUIST - Life Quality Based Intervention In Patients With Spine Tumors (Id 2020-00367)
• WALK-LSS – Muscle function and pelvic stability while walking in patients with symptomatic lumbar spinal stenosis
• Effect of decompression surgery on gait function: 12-month follow-up using inertial sensor based gait and attractor analysis
• Accelerometry-based physical activity, disability and quality of life before and after lumbar spine surgery: a prospective study
• Pre-operative gait asymmetry during a 6-minute walk test in patients with symptomatic lumbar spinal stenosis
• The analysis of bone microarchitecture and differentiation potential of subchondral, mesenchymal stromal cell in facet joint osteoarthritis
• Analysis of osteoarthritis-specific structural changes of subchondral bone compartments in degenerative lumbar facet joints
• Characterization of subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal
• Decompression surgery improves gait quality in patients with symptomatic lumbar spinal stenosis
• Severity of degenerative lumbar spinal stenosis affects pelvic rigidity during walking
• Association between fatty infiltration of paraspinal muscle, sagittal spinopelvic alignment and stenosis grade in patients with degenerative lumbar spinal stenosis

University Hospital Basel/ University Basel

• KWUB Knochen- und Weichteiltumorboard (Tumorzentrum USB)
• Onkologie
• Radioonkologie
• Wirbelsäulenzentrum USB
  • Schmerztherapie
  • Neurologie
  • Muskuloskeletale Radiologie
  • Psychosomatik
  • Infektiologie
  • Neurochirurgie
  • Orthopädie und Traumatologie
  • Notfallmedizin
  • Physiotherapie
  • Pflege

Institute for Psychology University Basel

National Collaborations

ETH Zürich «Institute for Biomechanics»
St. Clara Spital Basel
Hopital du Jura- Delemont 
Kantonspital Aarau
Kantonsspital Baselland
SGS Schweizer Gesellschaft für Spinale Chirurgie

International Collaborations

AO Spine: Knowledge Forum Tumor (various projects)
DGOU: Sektion Wirbelsäule: S2 Leitlinien Projekt: Wirbelsäulenmetastasen
BMB Spine Group (Basel- Milano-Budapest) Spine Tumors and Aging Spine

• CSS – Assessing The Course Of Degenerative Cervical Spine Stenosis Using Functional Outcomes (Id 2019-01270)
• MTRON - Metastatic Tumor Research And Outcomes Network Register Study (Id 2018-00129)
• Atrophylss - Association Between Lumbar Muscle Atrophy, Sagittal Pelvic Alignment And Stenosis Grade In Patients With Degenerative Lumbar Spinal Stenosis (Id 2020-00150)
• Musclss - Effect Of Muscle Fatigue On Spinal Imbalance And Motion In Lumbar Spinal Stenosis: Single Center Observational Pilot Study (Id 2021-02012)