This focal area covers the research activities of 13 teams and thus covers a very broad spectrum. All research topics are listed below.

• Development of new diagnostic methods for atrial fibrillation
• Diagnosis and therapy of cardiovascular disease
• Perioperative nutritional support and insulin administration
• Perioperative patient safety
• Physical activity and health with focus on vascular health
• Postoperative cognitive dysfunction and postoperative delirium
• Risk stratification of sudden cardiac death
• Surrogate markers of arteriosclerosis and vascular ultrasound
• Technologies of interventional therapy for atrial fibrillation

Hyperacute T Wave in the Early Diagnosis of Acute Myocardial Infarction. Koechlin L, Strebel I, Zimmermann T, Nestelberger T, Walter J, Lopez-Ayala P, Boeddinghaus J, Shrestha S, Arslani K, Stefanelli S, Reuthebuch B, Wussler D, Ratmann PD, Christ M, Badertscher P, Wildi K, Giménez MR, Gualandro DM, Miró Ò, Fuenzalida C, Martin-Sanchez FJ, Kawecki D, Bürgler F, Keller DI, Abächerli R, Reuthebuch O, Eckstein FS, Twerenbold R, Reichlin T, Mueller C; APACE investigators. Ann Emerg Med. 2023 Feb 9:S0196-0644(22)01327-0. doi: 10.1016/j.annemergmed.2022.12.003. Epub ahead of print. PMID: 36774205.

Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery.  Puelacher C, Gualandro DM, Glarner N, Lurati Buse G, Lampart A, Bolliger D, Steiner LA, Grossenbacher M, Burri-Winkler K, Gerhard H, Kappos EA, Clerc O, Biner L, Zivzivadze Z, Kindler C, Hammerer-Lercher A, Filipovic M, Clauss M, Gürke L, Wolff T, Mujagic E, Bilici M, Cardozo FA, Osswald S, Caramelli B, Mueller C; BASEL-PMI Investigators. Eur Heart J. 2023 Jan 27:ehac798. doi: 10.1093/eurheartj/ehac798. Epub ahead of print. PMID: 36705050.

Discrepancy in Reporting of Perioperative Complications: A Retrospective Observational Study. Gomes NV, Polutak A, Schindler C, Weber WP, Steiner LA, Rosenthal R, Dell-Kuster S. Ann Surg. 2023 Jan 24. doi: 10.1097/SLA.0000000000005807. Epub ahead of print. PMID: 36727743.

Quantifying inflammation using interleukin-6 for improved phenotyping and risk stratification in acute heart failure. Michou E, Wussler D, Belkin M, Simmen C, Strebel I, Nowak A, Kozhuharov N, Shrestha S, Lopez-Ayala P, Sabti Z, Mork C, Diebold M, Péquignot T, Rentsch K, von Eckardstein A, Gualandro DM, Breidthardt T, Mueller C. Eur J Heart Fail. 2023 Jan 4. doi: 10.1002/ejhf.2767. Epub ahead of print. PMID: 36597828.

Bleeding and ischaemic events after first bleed in anticoagulated atrial fibrillation patients: risk and timing. Meyre PB, Blum S, Hennings E, Aeschbacher S, Reichlin T, Rodondi N, Beer JH, Stauber A, Müller A, Sinnecker T, Moutzouri E, Paladini RE, Moschovitis G, Conte G, Auricchio A, Ramadani A, Schwenkglenks M, Bonati LH, Kühne M, Osswald S, Conen D. Eur Heart J. 2022 Dec 14;43(47):4899-4908. doi: 10.1093/eurheartj/ehac587. PMID: 36285887.

Clinical effect of obesity on N-terminal pro-B-type natriuretic peptide cut-off concentrations for the diagnosis of acute heart failure. Kozhuharov N, Martin J, Wussler D, Lopez-Ayala P, Belkin M, Strebel I, Flores D, Diebold M, Shrestha S, Nowak A, Gualandro DM, Michou E, Zimmermann T, Rentsch K, von Eckardstein A, Keller DI, Breidthardt T, Mueller C; BASEL V Investigators. Eur J Heart Fail. 2022 Sep;24(9):1545-1554. doi: 10.1002/ejhf.2618. Epub 2022 Aug 8. PMID: 35851710.

Low Cardiorespiratory Fitness Post-COVID-19: A Narrative Review. Schwendinger F, Knaier R, Radtke T, Schmidt-Trucksäss A. Sports Med. 2022 Sep 17:1–24. Epub ahead of print.

Case report of elevation of high-sensitivity cardiac troponin T in the absence of cardiac involvement in immune checkpoint inhibitor-associated myositis. Ruperti-Repilado FJ, van der Stouwe JG, Haaf P, Mueller C, Läubli H, Pfister O, Rothschild SI, Kuster GM.
Eur Heart J Case Rep. 2022 Aug 25;6(9):ytac353.

Skeletal Muscle Disorders: A Non-cardiac Source of Cardiac Troponin T. du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators. Circulation. 2022 Apr 7. doi: 10.1161/CIRCULATIONAHA.121.058489. Epub ahead of print. PMID: 35389756.

Characteristics and Outcomes of Type 2 Myocardial Infarction. Coscia T, Nestelberger T, Boeddinghaus J, Lopez-Ayala P, Koechlin L, Miró Ò, Keller DI, Strebel I, Yufera Sanchez A, Okamura B, Wussler D, Shrestha S, Hausknecht K, Martín-Sánchez FJ, Christ M, Kawecki D, Twerenbold R, Wildi K, Rubini Gimenez M, Mueller C; APACE Investigators. JAMA Cardiol. 2022 Apr 1;7(4):427-434. doi: 10.1001/jamacardio.2022.0043. PMID: 35262640; PMCID: PMC8908230.

Silent brain infarcts impact on cognitive function in atrial fibrillation. Kühne M, Krisai P, Coslovsky M, Rodondi N, Müller A, Beer JH, Ammann P, Auricchio A, Moschovitis G, Hayoz D, Kobza R, Shah D, Stephan FP, Schläpfer J, Di Valentino M, Aeschbacher S, Ehret G, Eken C, Monsch A, Roten L, Schwenkglenks M, Springer A, Sticherling C, Reichlin T, Zuern CS, Meyre PB, Blum S, Sinnecker T, Würfel J, Bonati LH, Conen D, Osswald S; Swiss-AF Investigators. Eur Heart J. 2022 Feb 17:ehac020. doi: 10.1093/eurheartj/ehac020. Epub ahead of print. PMID: 35171989.

Future application of point of care high-sensitivity cardiac troponin testing in the Emergency Department. Body R, Mills NL, Mueller C.Eur Heart J Acute Cardiovasc Care. 2022 Jan 3:zuab125. doi: 10.1093/ehjacc/zuab125. Epub ahead of print. PMID: 34977937.

Long-term beta-blocker treatment in stable patients after myocardial infarction: a potential impact due to changes in the diagnosis of myocardial infarction? van der Stouwe JG, Boeddinghaus J, Mueller C.Eur Heart J. 2022 Feb 22;43(8):834-835. doi: 10.1093/eurheartj/ehab257. PMID: 34023894.

Diagnostic Performance of the European Society of Cardiology 0/1-h Algorithms in Late Presenters. Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Koechlin L, Buechi M, Miro O, Keller DI, Gimenez MR, Twerenbold R, Mueller C; APACE Investigators. J Am Coll Cardiol. 2021 Mar 9;77(9):1264-1267. doi: 10.1016/j.jacc.2021.01.004. PMID: 33663745.

Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation. Aeschbacher S, Blum S, Meyre PB, Coslovsky M, Vischer AS, Sinnecker T, Rodondi N, Beer JH, Moschovitis G, Moutzouri E, Hunkeler C, Burkard T, Eken C, Roten L, Zuern CS, Sticherling C, Wuerfel J, Bonati LH, Conen D, Osswald S, Kühne M; Swiss-AF Investigators*. Hypertension. 2021 Feb;77(2):662-671. doi: 10.1161/HYPERTENSIONAHA.120.16025. Epub 2020 Dec 28. PMID: 33356398; PMCID: PMC7803457.

Rhabdomyolysis: A Noncardiac Source of Increased Circulating Concentrations of Cardiac Troponin T? Giger RD, du Fay de Lavallaz J, Prepoudis A, Stoll T, Lopez-Ayala P, Glarner N, Boeddinghaus J, Puelacher C, Nestelberger T, Mueller C.J Am Coll Cardiol. 2020 Dec 1;76(22):2685-2687. doi: 10.1016/j.jacc.2020.08.088.

Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial. Jeger RV, Farah A, Ohlow MA, Mangner N, Möbius-Winkler S, Weilenmann D, Wöhrle J, Stachel G, Markovic S, Leibundgut G, Rickenbacher P, Osswald S, Cattaneo M, Gilgen N, Kaiser C, Scheller B BASKET-SMALL 2 Investigators.; Lancet. 2020 Oct 19:S0140-6736(20)32173-5. doi: 10.1016/S0140-6736(20)32173-5. Epub ahead of print. PMID: 33091360.

Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial. Fahrni G, Scheller B, Coslovsky M, Gilgen N, Farah A, Ohlow MA, Mangner N, Weilenmann D, Wöhrle J, Cuculi F, Leibundgut G, Möbius-Winkler S, Zweiker R, Twerenbold R, Kaiser C, Jeger R; BASKET-SMALL 2 Investigators. Clin Res Cardiol. 2020 Jan 29. doi: 10.1007/s00392-020-01603-2. [Epub ahead of print]

Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial.Kozhuharov N, Goudev A, Flores D, Maeder MT, Walter J, Shrestha S, Gualandro DM, de Oliveira Junior MT, Sabti Z, Müller B, Noveanu M, Socrates T, Ziller R, Bayés-Genís A, Sionis A, Simon P, Michou E, Gujer S, Gori T, Wenzel P, Pfister O, Conen D, Kapos I, Kobza R, Rickli H, Breidthardt T, Münzel T, Erne P, Mueller C; GALACTIC Investigators. JAMA. 2019 Dec 17;322(23):2292-2302. doi: 10.1001/jama.2019.18598.

Predicting Major Adverse Events in Patients With Acute Myocardial Infarction. Nestelberger T, Boeddinghaus J, Wussler D, Twerenbold R, Badertscher P, Wildi K, Miró Ò, López B, Martin-Sanchez FJ, Muzyk P, Koechlin L, Baumgartner B, Meier M, Troester V, Rubini Giménez M, Puelacher C, du Fay de Lavallaz J, Walter J, Kozhuharov N, Zimmermann T, Gualandro DM, Michou E, Potlukova E, Geigy N, Keller DI, Reichlin T, Mueller C; APACE Investigators. J Am Coll Cardiol. 2019 Aug 20;74(7):842-854. doi: 10.1016/j.jacc.2019.06.025.

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction. Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S. N Engl J Med. 2019 Jun 27;380(26):2529-2540. doi: 10.1056/NEJMoa1803377.

Prospective validation of N-terminal pro B-type natriuretic peptide cut-off concentrations for the diagnosis of acute heart failure. Kozhuharov N, Sabti Z, Wussler D, Nowak A, Badertscher P, Twerenbold R, Wildi K, Stallone F, Vogt F, Hilti J, Puelacher C, du Fay de Lavallaz J, Shrestha S, Flores D, Nestelberger T, Koechlin L, Boeddinghaus J, Zimmermann T, Walter J, Schumacher C, Rentsch K, von Eckardstein A, Keller DI, Goudev A, Pfister O, Breidthardt T, Mueller C; BASEL V Investigators. Eur J Heart Fail. 2019 Jun;21(6):813-815. doi: 10.1002/ejhf.1471. Epub 2019 Apr 24.

Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation. Conen D, Rodondi N, Müller A, Beer JH, Ammann P, Moschovitis G, Auricchio A, Hayoz D, Kobza R, Shah D, Novak J, Schläpfer J, Di Valentino M, Aeschbacher S, Blum S, Meyre P, Sticherling C, Bonati LH, Ehret G, Moutzouri E, Fischer U, Monsch AU, Stippich C, Wuerfel J, Sinnecker T, Coslovsky M, Schwenkglenks M, Kühne M, Osswald S; Swiss-AF Study Investigators. J Am Coll Cardiol. 2019 Mar 12;73(9):989-999. doi: 10.1016/j.jacc.2018.12.039.

B-Type Natriuretic Peptides and Cardiac Troponins for Diagnosis and Risk-Stratification of Syncope. du Fay de Lavallaz J, Badertscher P, Nestelberger T, Zimmermann T, Miró Ò, Salgado E, Christ M, Geigy N, Cullen L, Than M, Martin-Sanchez FJ, Di Somma S, Peacock WF, Morawiec B, Walter J, Twerenbold R, Puelacher C, Wussler D, Boeddinghaus J, Koechlin L, Strebel I, Keller DI, Lohrmann J, Michou E, Kühne M, Reichlin T, Mueller C. Circulation. 2019 Feb 25. doi: 10.1161/CIRCULATIONAHA.118.038358. [Epub ahead of print]

External Validation of the MEESSI Acute Heart Failure Risk Score: A Cohort Study. Wussler D, Kozhuharov N, Sabti Z, Walter J, Strebel I, Scholl L, Miró O, Rossello X, Martín-Sánchez FJ, Pocock SJ, Nowak A, Badertscher P, Twerenbold R, Wildi K, Puelacher C, du Fay de Lavallaz J, Shrestha S, Strauch O, Flores D, Nestelberger T, Boeddinghaus J, Schumacher C, Goudev A, Pfister O, Breidthardt T, Mueller C. Ann Intern Med. 2019 Feb 19;170(4):248-256. doi: 10.7326/M18-1967. Epub 2019 Jan 29.