Research | Department of Clinical Research

Academic clinical research

Research at our department is focused on unmet medical and patient-oriented needs. They arise from clinical practice and encompass almost all medical disciplines.

DKF research groups carry out numerous independent clinical research projects. They are often supported by the DKF Scientific Services. Here we present some of the projects in more detail.

[Translate to English:] BRACE-AFib-Studie

Investigator-initiated Clinical Trial (IICT)

BRACE-AFib study

Beta-blocker Replacement And Calcium channel blockers Evaluation in Atrial Fibrillation

Investigator-Initiated Clinical trial (IICT)

NoDoubt study

Efficacy of non-opioid drugs in addition to opioid therapy for cancer pain management: a double-blind, randomized, three arm, placebo-controlled trial assessing the key non-opioids dipyrone (metamizole) and ibuprofen: NoDoubt-trial

Cohort/Register

SWISS-CASCADE

Swiss Cancer Genetic Predisposition Cascade Screening

Research groups at the DKF

Publications

Investigator-initiated clinical trial (IICT)

DISTAL study

Endovascular therapy plus best medical treatment (BMT) versus BMT alone for medium vessel occlusion stroke - a pragmatic, international, multicentre, randomized trial

Investigator-initiated clinical trial (IICT)

dreaMS_V2

Development of Digital Biomarkers in Multiple Sclerosis (Validation Study 2)

Investigator-initiated clinical trial (IICT)

EMINENT-ICH study

Early minimally invasive image-guided endoscopic evacuation of intracerebral haemorrhage: a randomized controlled trial

Investigator-initiated clinical trial (IICT)

ESTREL study

Enhancement of stroke rehabilitation with Levodopa: A randomized controlled trial

Investigator-initiated clinical trial (IICT)

ICARUS study

Intracranial atherosclerosis related large-vessel occlusion treated with urgent stenting - a pragmatic, international, multicentre, randomized trial

Investigator-initiated clinical trial (IICT)

KIDS-STEP study

Betamethasone Therapy in Hospitalized Children with Community-aquired Pneumonia (CAP)

Investigator-initiated clinical trial (IICT)

LIPS study

Combination antibiotic treatment with linezolid for Staphylococcus aureus bacteraemia: a randomized controlled trial

Investigator-Initiated Clinical Trial (IICT)

LYMPH study

Surgical versus conservative complex physical decongestion Therapy (CDT) for chronic breast cancer-related lymphedema (BCRL): A pragmatic, randomized, multicenter superiority trial

Investigator-Initiated Clinical Trial

MultiSCRIPT study

Personalized medicine in multiple sclerosis a pragmatic platform trial embedded within SMSC

Data research

NCCR AntiResist

National Centre of Competence in Research "New approaches to combat antibiotic-resistant bacteria"

Cohort/Registry

NOACISP

New Oral Anticoagulants in Stroke Patients

Investigator-initiated clinical trial (IICT)

OxyTUTION study

Oxytocin substitution therapy in patients with central diabetes insipidus: a double-blind randomized-controlled trial

Investigator-initiated clinical trial (IICT)

PFOA II study

Treatment of patellofemoral osteoarthritis with nasal chondrocyte-based engineered cartilage (N-TEC) implantation in a randomized, controlled, multi-center phase II clinical trial

Investigator-initiated clinical trial (IICT)

PREPEC study

Pre- versus sub-pectoral implant-based breast reconstruction after skin- and nipple-sparing mastectomy: A pragmatic, multicenter, randomized, superiority trial

Investigator-initiated clinical trial (IICT)

RELIEF study

Restricted versus liberal fluid intake for prevention of bronchopulmonary dysplasia - a cluster-randomized multiple period cross-over trial

Cohort/Registry

SOL-DHR

Swiss Organ Living-Donor Health Registry

Cohort/Registry

SwissAF

Swiss Atrial Fibrillation Cohort

Cohort/Registry

SMSC

Swiss Multiple Sclerosis Cohort

Cohort/Registry

SSR

Swiss Stroke Registry

Cohort/Registry

STCS

Swiss Transplant Cohort Study

Investigator-initiated clinical trial (IICT)

TAXIS study

Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with clinically node-positive breast cancer

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Academic clinical research

Investigator-initiated Clinical Trial (IICT)

BRACE-AFib study

Investigator-Initiated Clinical trial (IICT)

NoDoubt study

Cohort/Register

SWISS-CASCADE

Research groups at the DKF