Annegret Mündermann

Prof. Dr.
Annegret Mündermann PhD

Research Director Functional Biomechanics, Department of Orthopaedics and Traumatology, University Hospital Basel; affiliated with Department of Biomedical Engineering and Department Clinical Research, University of Basel

University Hospital Basel

+41 61 328 54 45


Research Group Annegret Mündermann


Research Focus

Regenerative Medicine & Biomechanics

Area of Research

In vivo mechanosensitivity of musculoskeletal tissue; Diagnostics, prevention and therapy of disease related gait and movement patterns; Innovation and product development

Approved Research Projects

We strive to solve clinically motivated questions on diseases and conditions of the musculoskeletal system and to translate results of laboratory studies into the clinic.

Our research topics are

  • In vivo mechanosensitivity of musculoskeletal tissue
  • Diagnostics, prevention and therapy of disease related gait and movement patterns
  • Innovation and product development

For our current projects, we recruit

  • participants with osteoarthritis at the knee or hip
  • participants who have received a total knee or hip replacement
  • participants scheduled to receive a high tibial osteotomy
  • participants with lumbar spinal stenosis
  • participants with rotator cuff tear
  • healthy persons

Please contact Prof. Dr. Annegret Mündermann for details on current projects.

In vivo mechanosensitivity of musculoskeletal tissue

The core of biomechanics is the influence of forces on biological organisms. The importance of the tight interplay between mechanical and biological factors in health and disease receives increasing scientific scrutiny. In a series of laboratory studies, we study the in vivo mechanosensitivity of involved tissues in humans with the ultimate goal of designing interventions—mechanical or pharmaceutical—that prevent or delay the onset of osteoarthritis or slow down its rate of progression. These projects are currently funded through the Swiss National Science Foundation and Industry grants.

Diagnostics, prevention and therapy of disease related gait and movement patterns

The important task in collaboration with the therapy services in the coming years is to establish the diagnostics based on movement analysis. Understanding biomechanical factors as risk factors or osteoarthritis is a critical component in prevention and therapy. We combine novel portable inertial sensor systems with gold-standard camera based motion analysis to identify factors relevant for injury and disease mechanisms and treatment. More recently, we have initiated research on the effects of manual therapy on ambulatory mechanics. Our current clinical projects include:

  • Trunk Muscle Strength, Strength Endurance and Activity in Persons With Low Back Pain
  • The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis
  • Gait Asymmetry Assessed Using Portable Gait Analysis System
  • Muscle function and dynamic and postural stability in patients receiving hip or knee arthroplasty
  • Gait Analysis During Level and Uphill Walking After Lengthening Osteotomy of the Lateral Column
  • Surgical Versus Conservative Treatment of Weber B1 Fracture: Functional Outcome Using Gait Analysis


Innovation and product development

In recent years, members of the Clinic for Orthopaedics and Traumatology have initiated several technical innovations and products. These included novel endoprostheses aimed at improving joint function and improved crutch cuff designs to reduce symptoms and complaints associated with crutch walking. Currently, we work on establishing protocols for IMU gait analysis and for measuring shoulder translation in clinical practice.


    National Collaborations

    International Collaborations

    Ongoing Research Projects


    Research Team

    Dr. phil. Corina Nüesch

    Associate Head Functional Biomechanics

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    Dr. med. Petros Ismailidis

    Research Fellow

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