Bettina Wölnerhanssen

PD Dr. med.
Bettina Wölnerhanssen

Head of St. Clara Research AG

St. Clara Hospital Basel

Phone +41 61 685 84 00



Research Focus

Endocrinology, Metabolism & Developmental Disorders

Area of Research

One goal of our research is to deepen our understanding of the mechanisms of action of metabolic surgery in order to optimize the surgical strategy and to get to the bottom of the causes of obesity. We are also studying physiological appetite and saturation regulation as well as central reward mechanisms and changes in obesity. We also investigate the metabolic effects of different food substrates, especially sugars and sugar substitutes.

Approved Research Projects


2018-2020 Research Grant Uniscientia Foundation: 1) Long-term adverse effects after bariatric surgery (Barrett esophagus, bone density), and 2) mTORC2 activity in adipose tissue

2019-2021 Research Grant Botnar Foundation: Effect of the natural sweeteners erythritol and xylitol on gut microbiota and metabolic function and clinical application in obese children.

2020-2024 Research Grant Swiss Science Foundation: Understanding gut-brain interactions and the effect of a low-carb dietary intervention in obese and depressive patients with and without glucose intolerance or diabetes: a pilot trial



National Collaborations
USZ Gastroenterologie (Ch. Gubler) und USZ Viszeralchirurgie (M. Büeter, D, Vetter), Biozentrum (M. Shimobayashi), KS Luzern (S. Fischli)

International Collaborations
KU Leuven (L. van Oudenhove), Conway Institute University College Dublin (C. le Roux), University of Copenhagen (J. Holst), Rigshospitalet Copenhagen (J. Rehfeld)


Ongoing Research Projects


PolyAlluLac Trial: Acute effects of the two alternative sweeteners D-allulose and erythritol on gastrointestinal hormone secretion and glycemic control (NCT04027283)

PolyVasc Trial: Effect of the Natural Sweeteners Erythritol and Xylitol on Vascular Function in Obese Volunteers (NCT02821923)

Taste 2 Trial: Taste Physiology in Obese Volunteers Before and After Bariatric Surgery (NCT02902198)

FUB B Trial: Long-term adverse effects after laparoscopic sleeve gastrectomy and Roux-Y-Gastric Bypass: PART B (Oesophagus) (NCT03410849)


Research Team

PD Dr. phil. Anne Christin Meyer-Gerspach

Research Fellow

Phone +41 61 685 86 44


Valentine Bordier

Research Fellow

Phone -


Anke Etter-Atlass

Study Nurse

Phone +41 61 685 86 33


Therese Benkert

Research Fellow

Phone +41 61 685 89 37


Uta Ruscher

Study Nurse

Phone +41 61 685 89 87