PD Dr. med.
Head of St. Clara Research AG
St. Clara Hospital Basel
Phone +41 61 685 84 00
Research Group Bettina Wölnerhanssen
Endocrinology, Metabolism & Developmental Disorders
Area of Research
One goal of our research is to deepen our understanding of the mechanisms of action of metabolic surgery in order to optimize the surgical strategy and to get to the bottom of the causes of obesity. We are also studying physiological appetite and saturation regulation as well as central reward mechanisms and changes in obesity. We also investigate the metabolic effects of different food substrates, especially sugars and sugar substitutes.
Approved Research Projects
2018-2020 Research Grant Uniscientia Foundation: 1) Long-term adverse effects after bariatric surgery (Barrett esophagus, bone density), and 2) mTORC2 activity in adipose tissue
2019-2021 Research Grant Botnar Foundation: Effect of the natural sweeteners erythritol and xylitol on gut microbiota and metabolic function and clinical application in obese children.
2020-2024 Research Grant Swiss Science Foundation: Understanding gut-brain interactions and the effect of a low-carb dietary intervention in obese and depressive patients with and without glucose intolerance or diabetes: a pilot trial
USZ Gastroenterologie (Ch. Gubler) und USZ Viszeralchirurgie (M. Büeter, D, Vetter), Biozentrum (M. Shimobayashi), KS Luzern (S. Fischli)
KU Leuven (L. van Oudenhove), Conway Institute University College Dublin (C. le Roux), University of Copenhagen (J. Holst), Rigshospitalet Copenhagen (J. Rehfeld)
Ongoing Research Projects
PolyAlluLac Trial: Acute effects of the two alternative sweeteners D-allulose and erythritol on gastrointestinal hormone secretion and glycemic control (NCT04027283)
PolyVasc Trial: Effect of the Natural Sweeteners Erythritol and Xylitol on Vascular Function in Obese Volunteers (NCT02821923)
Taste 2 Trial: Taste Physiology in Obese Volunteers Before and After Bariatric Surgery (NCT02902198)
FUB B Trial: Long-term adverse effects after laparoscopic sleeve gastrectomy and Roux-Y-Gastric Bypass: PART B (Oesophagus) (NCT03410849)