Matthias Johannes Betz

PD Dr. med.
Matthias Johannes Betz

Senior physician
Head of Translational Metabolism

University Hospital Basel

Phone +41 61 556 56 54



Research Focus

Endocrinology, Metabolism & Developmental Disorders

Area of Research

Our research is focused on the endocrine factors involved in human thermogenesis and energy metabolism. Specifically, we investigate human brown adipose tissue and cold induced thermogenesis.

Approved Research Projects

2015 – 2018 Research grant, Goldschmid-Jacobson Foundation / Medical Faculty, University of Basel
2015 Young Independent Investigator Grant of the Swiss Society for Endocrinology and Diabetes (SGED)
2016 SNSF ambizione SCORE grant for research project on influence of glucocorticoids on human brown adipose tissue
2017 Grant from Bangerter-Rhyner foundation for research project on brown adipose tissue
2021 – 2025 SNSF Project grant: Therapeutic Targeting of the cAMP and cGMP Pathway to Increase Brown Adipose Tissue Activity in Humans


    National Collaborations
    - Prof. Christian Wolfrum, Department of Health Sciences and Technology, ETH-Zürich
    - Prof. Nicola Zamboni, Institute of Systems Biology, ETH-Zürich
    - Prof. Dr. Irene Burger, Dept. of Nuclear Medicine, University Hospital Zurich
    - Prof. Ender Konukoglu, ETH Zurich, Biomedical Image Computing
    - Prof. Bart Deplancke, EPFL, Lausanne

    International Collaborations
    - Prof. Sven Enerbäck, University of Gothenburg, Sahlgrenska Akademin
    - Prof. Dr. Jörg Heeren, University Hospital Eppendorf, Hamburg, Germany

    Ongoing Research Projects

    NEXT Trial: Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis (NCT05711199)

    BANDIT Trial: Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis (NCT06078345)


    Completed Research Projects

    ASCENT Trial: Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue (Clinical trials NCT05294965)

    InoBAT Trial: Inosine Energy Expenditure Study (Clinical trials NCT04476238)

    GlucoBAT Trial: Influence of short-term high dose glucocorticoid administration on brown adipose tissue function (NCT03269747)

    HEAT Trial: Influence of anti-adrenergic therapy on energy metabolism in patients with primary hyperthyroidism (NCT03379181)

    MATCH-Study: Metabolomics of Thyroid Hormones in Humans

    Research Team

    Dr. med. Claudia Irene Maushart

    Post-Doc / Physician

    Phone +41 61 328 63 89


    Anninja Lea Isenrich

    Physician / MD Student

    Phone -

    Rahel Catherina Löliger

    Physician / MD Student

    Phone +41 61 328 57 43


    Dr. med. Jaël Rut Senn

    Post-Doc / Physician

    Phone +41 61 328 45 86

    Dr. med. Laila Füchtbauer

    Research fellow, Physician

    Phone +41 61 556 50 73