Martin Siegemund

Prof. Dr. med.
Martin Siegemund

Deputy Chief Physician Intensive Care Unit Anaesthesiology

University Hospital Basel

Phone +41 61 328 64 14



Research Focus

Critical Care & Respiratory Medicine

Area of Research

Sepsis, with a focus on acute therapy of severe sepsis and septic and hemorrhagic shock, specifically the influence of crystalloid and colloidal fluids and blood products on course and outcome in ICU patients

Approved Research Projects

Delirium(recruitment ended or study published):

  • BADEN Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDE): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. PMID: 33120302 and PMID: 29482596
  • Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis: PMID: 30238227
  • Reviews: PMID: 26456271, PMID: 31263968
  • Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial: PMID: 28710219

Nutrition / GIT

  • The Basel Enteral High Protein Study (BEntHiPro): NCT02678325
  • Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU (SUP-ICU): DOI: 10.1056 / NEJMoa1714919

Volume resuscitation / Sepsis (recruitment ended or study published):

  • Impact of amount of fluid for circulatory resuscitation on renal function in patients in shock: evaluating the influence of intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water measured by bio-impedance analysis on hemodynamic parameters for guidance of volume resuscitation in shock therapy: a protocol for the VoluKid pilot study – an observational clinical trial:
  • Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting (Volu-CABG): NCT04533698
  • Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC): NCT02079402

Oxygen Therapy

Past studies:

  • Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure (HOT-ICU): DOI: 10.1056 / NEJMoa2032510


    National Collaborations

    International Collaborations

    Ongoing Research Projects

    Oxygen Therapy

    Ongoing studies:

    • Handling Oxygenation Targets in COVID-10 (HOT-COVID): NCT04425031

    Atrial Fibrillation

    Ongoing studies:

    • Non-invasive Evaluation of New-onset Atrial Fibrillation After Cardiac Surgery The Basel CardioInsightTM - 3D Mapping (BigMap) Study: NCT04964765


    Ongoing studies:

    • Circadian Melatonin Rhythms in Critically Ill Patients With Delirium: NCT04721613
    • Study protocol for a prospective randomized double-blind placebo-controlled clinical trial investigating a Bett Outcome with Melatonin compared to Placebo Administered to normalize sleep-wake cycle and treat hypoactive ICU Delirium: The Basel BOMP-AID study: PMID: 32354780


    Nutrition / GIT

    Ongoing studies:

    • Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients – a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study: PMID: 32843075


    Volume resuscitation / Sepsis

    Ongoing studies:

    01/11/22 4

    • Prospective Study to Discover New Biomarkers for Early Detection of Sepsis and Prediction of Sepsis-related Mortality in Patients With Severe Community Acquired Pneumonia (sCAP OMICS Study): NCT04280354
    • NCCR AntiResist: Mono-center Study to Identify New Approaches to Combat Antibiotic-resistant Bacteria. NCT05017766

    Coagulation / Blood Transfusion

    Planned studies:

    • Basel Bedside Assessment of Microcirculatory Transfusion Levels II: Microcirculation dependent Red Blood Cell Transfusion Thresholds: A prospective, randomized-controlled, single-centre interventional study (BaMiTral II)

    Ongoing studies:

    • Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Van Willebrand Factor (The Basel Will-Plate Study): NCT04555785

    Research Team

    PD Dr. med. Alexa Hollinger 


    Phone +41 61 556 58 95

    Dr. Rita Achermann 


    Phone +41 61 328 54 25

    cand. med. Nuria Zellweger 

    Scientific Support

    Phone +41 61 328 40 73