Research Focus

Neurology

Area of Research

Planning and conducting large multicenter international stroke studies to provide a more precise information (i.e. precision medicine approach) for A) an advanced early risk stratification after stroke and B) novel risk factor identification in primary prevention as well as C) a better identification of the underlying stroke etiology for an improved secondary prevention. Use the gained knowledge to design and conduct meaningful randomized controlled trials to ultimately improve clinical practice.

• Coordination of the Swiss Stroke Registry 
• COSMOS study
• CoRisk study: Copeptin for Risk stratification in acute stroke patients study.
• The northern Manhattan study: Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk.
• NOMAS study: The role of copeptin, midregional natriuretic peptide and procalcitonin as markers of ischemic stroke risk in the Northern Manhattan study (SNF funded) 
• BIOSIGNAL study: Biomarker signature of stroke aetiology study (SNF funded) 
• MOSES study: MidregiOnal proatrial natriuretic peptide to guide SEcondary Stroke prevention (SNF funded)
• DISTAL study: Mechanical thrombectomy for Medium Vessel Occlusion stroke – a pragmatic, multicentre, randomized trial with blinded outcome assessment (DISTAL)-Trial (SNF funded)
• TECNO study: Safety and efficacy of intra-arterial thrombolytics: A study on Tenecteplase for non-complete reperfusion of intracranial occlusions (SNF funded)
• ROXANE (funding: Herzstiftung, SAMW)
• CRESCENDO (funding : ERANET)
• UMBREALLA (funding : Horizon/ SERI)

National Collaborations

• Prof. Mirjam Christ-Crain & Prof. Katherine Rentsch (USB)
• Prof. Catherine Jutzeler (ETH)
• Prof. Marcel Arnold, PD Dr. David Seiffge, PD Dr. Johannes Käsmacher, Prof. Alexander Leichtle (Uni Bern)
• Prof. Jean-Charles Sanchez & Prof. Emmanuel Carrera (Uni Genf)
• Prof. Arnold von Eckardstein & Prof. Susanne Wegener & Prof. Andreas Luft (USZ)
• Prof. Patrik Michel (CHUV)
• PD Dr. Carlo Cereda (Lugano)
• PD Dr. Georg Kägi (St. Gallen)
• Prof. Krassen Nedeltchev & PD Dr. Timo Kahles (Aarau)

International Collaborations

• Dr. Else Sandset (Norway)
• Prof. Mitchell Elkind (USA)
• Prof. Joan Montaner (Spain)
• Prof. Peter Kelly (Ireland)
• Prof. Andreas Meisel (Germany)
• Prof. Heinrich Audebert (Germany)
• Prof. Christian Förch (Germany)
• Prof. Jesse Dawson (UK)

• Coordination of the Swiss Stroke Registry
• MOSES study: MidregiOnal proatrial natriuretic peptide to guide SEcondary Stroke prevention (SNF funded)
• DISTAL study: Mechanical thrombectomy for Medium Vessel Occlusion stroke – a pragmatic, multicentre, randomized trial with blinded outcome assessment (DISTAL)-Trial (SNF funded)
• TECNO study: Safety and efficacy of intra-arterial thrombolytics: A study on Tenecteplase for non-complete reperfusion of intracranial occlusions (SNF funded)