Endocrinology, Metabolism & Developmental Disorders

The clinical research groups in this focal area are dedicated to a broad spectrum of disease patterns. On the one hand, the research efforts are focussing on diabetes, obesity, diseases of the pituitary gland, thyroid gland, adrenal glands and bone, on the other hand on reproductive endocrinology and congenital developmental disorders as well as pregnancy complications.

Selected current publications

A randomized controlled trial of GLP-1 receptor agonist dulaglutide in primary polydipsia. Winzeler B, Sailer CO, Coynel D, Zanchi D, Vogt DR, Urwyler SA, Refardt J, Christ-Crain M. J Clin Invest. 2021 Sep 2:151800. doi: 10.1172/JCI151800. Epub ahead of print. PMID: 34473645.

Syndrome of inappropriate antidiuretic hormone secretion and hypothalamic hypocortisolism in neuromyelitis optica. Tsagkas C, Schäfer S, Baumgartner A, Müller J, Sinnecker T, Mehling M, van der Stouwe JG, Felder S, Panagiotou A, Potlukova E, Winzeler B, Scholz MC, Timper K, Blackham K, Nickel CH, Christ-Crain M, Bingisser R, Lyrer P, Kappos L, Yaldizli Ö. Lancet. 2021 Jun 5;397(10290):2194. doi: 10.1016/S0140-6736(21)00986-7. PMID: 34090605.

Individualized Nutritional Support for Hospitalized Patients With Chronic Heart Failure. Hersberger L, Dietz A, Bürgler H, Bargetzi A, Bargetzi L, Kägi-Braun N, Tribolet P, Gomes F, Hoess C, Pavlicek V, Bilz S, Sigrist S, Brändle M, Henzen C, Thomann R, Rutishauser J, Aujesky D, Rodondi N, Donzé J, Stanga Z, Mueller B, Schuetz P. J Am Coll Cardiol. 2021 May 11;77(18):2307-2319.

Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in Children. Burckhardt MA, Gotta V, Beglinger S, Renggli L, Bachmann S, Hess M, Rentsch K, Pfister M, Koch G, Davis EA, Zumsteg U, Jones TW, Szinnai G.  J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa568. doi: 10.1210/clinem/dgaa568. PMID: 32835363.

Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1β. Hepprich M, Wiedemann SJ, Schelker BL, Trinh B, Stärkle A, Geigges M, Löliger J, Böni-Schnetzler M, Rudofsky G, Donath MY. Cell Metab. 2020 Mar 12. pii: S1550-4131(20)30072-3. doi: 10.1016/j.cmet.2020.02.013. [Epub ahead of print]

A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate Antidiuresis. Refardt J, Imber C, Sailer CO, Jeanloz N, Potasso L, Kutz A, Widmer A, Urwyler SA, Ebrahimi F, Vogt DR, Winzeler B, Christ-Crain M. J Am Soc Nephrol. 2020 Feb 4. pii: ASN.2019090944. doi: 10.1681/ASN.2019090944. [Epub ahead of print]

Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study. Winzeler B, Cesana-Nigro N, Refardt J, Vogt DR, Imber C, Morin B, Popovic M, Steinmetz M, Sailer CO, Szinnai G, Chifu I, Fassnacht M, Christ-Crain M. The Lancet. 2019 Aug 17;394(10198):587-595. doi: 10.1016/S0140-6736(19)31255-3. Epub 2019 Jul 11.

Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial. Schuetz P, Fehr R, Baechli V, Geiser M, Deiss M, Gomes F, Kutz A, Tribolet P, Bregenzer T, Braun N, Hoess C, Pavlicek V, Schmid S, Bilz S, Sigrist S, Brändle M, Benz C, Henzen C, Mattmann S, Thomann R, Brand C, Rutishauser J, Aujesky D, Rodondi N, Donzé J, Stanga Z, Mueller B. The Lancet. 2019 Jun 8;393(10188):2312-2321. doi: 10.1016/S0140-6736(18)32776-4. Epub 2019 Apr 25

Association Between Glycemic Control and Risk of Fracture in Diabetic Patients: A Nested Case-Control Study. Vavanikunnel J, Charlier S, Becker C, Schneider C, Jick SS, Meier CR, Meier C. J Clin Endocrinol Metab. 2019 May 1;104(5):1645-1654. doi: 10.1210/jc.2018-01879.

Exome sequencing of fetal anomaly syndromes: novel phenotype-genotype discoveries. Meier N, Bruder E, Lapaire O, Hoesli I, Kang A, Hench J, Hoeller S, De Geyter J, Miny P, Heinimann K, Chaoui R, Tercanli S, Filges I. Eur J Hum Genet. 2019 May;27(5):730-737. doi: 10.1038/s41431-018-0324-y. Epub 2019 Jan 24.

Resolution of Hypothyroidism Restores Cold-Induced Thermogenesis in Humans. Maushart CI, Loeliger R, Gashi G, Christ-Crain M, Betz MJ. Thyroid. 2019 Apr;29(4):493-501. doi: 10.1089/thy.2018.0436. Epub 2019 Mar 8.

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. Fenske W, Refardt J, Chifu I, Schnyder I, Winzeler B, Drummond J, Ribeiro-Oliveira A Jr, Drescher T, Bilz S, Vogt DR, Malzahn U, Kroiss M, Christ E, Henzen C, Fischli S, Tönjes A, Mueller B, Schopohl J, Flitsch J, Brabant G, Fassnacht M, Christ-Crain M. N Engl J Med. 2018 Aug 2;379(5):428-439. doi: 10.1056/NEJMoa1803760.