Immunologie & Infektiologie

Das Forschungsspektrum dieses Schwerpunkts ist breit gefächert. Es reicht vom Studium pathophysiologischer Prozesse multiresistenter Keime über die Optimierung von Therapien verschiedenster entzündlicher Erkrankungen bis zur Erforschung der Gründe und Auswirkungen von Impfskepsis. 


Auswahl aktueller Publikationen

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Kaymak T, Kaya B, Wuggenig P, Nuciforo S, Göldi A; Swiss EoE Cohort Study Group (SEECS), Oswald F, Roux J, Noti M, Melhem H, Hruz P, Niess JHGut. 2022 May 25:gutjnl-2022-327166. Epub ahead of print.

How can patients with Clostridioides difficile infection on concomitant antibiotic treatment be best managed? Fitzpatrick F, Safdar N, van Prehn J, Tschudin-Sutter SLancet Infect Dis. 2022 May 23:S1473-3099(22)00274-2. Epub ahead of print.

Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial. Darie AM, Khanna N, Jahn K, Osthoff MBassetti S, Osthoff M, Schumann DM, Albrich WC, Hirsch H, Brutsche M, Grize L, Tamm M, Stolz DLancet Respir Med. 2022 May 23:S2213-2600(22)00086-8. Epub ahead of print. 

Skeletal Muscle Disorders: A Non-cardiac Source of Cardiac Troponin T. du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators. Circulation. 2022 Apr 7. doi: 10.1161/CIRCULATIONAHA.121.058489. Epub ahead of print. PMID: 35389756.

Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE; Swiss HIV Cohort Study. Clin Infect Dis. 2021 Nov 2;73(9):1597-1604.

Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans. Aguilar-Bultet L, Bagutti C, Egli A, Alt M, Maurer Pekerman L, Schindler R, Furger R, Eichenberger L, Roloff T, Steffen I, Huebner P, Stadler T, Tschudin-Sutter S. Clin Infect Dis. 2021 Jul 15;73(2):332-335. doi: 10.1093/cid/ciaa1164. PMID: 32776135; PMCID: PMC8282321.

Effect of Bedside Compared With Outside the Room Patient Case Presentation on Patients' Knowledge About Their Medical Care : A Randomized, Controlled, Multicenter Trial Becker C, Gamp M, Schuetz P, Beck K, Vincent A, Hochstrasser S, Metzger K, Widmer M, Thommen E, Mueller B, Fux CA, Leuppi JD, Schaefert R, Langewitz W, Trendelenburg M, Breidthardt T, Eckstein J, Osthoff M, Bassetti S, Hunziker S. . Ann Intern Med. 2021 Jun 29. doi: 10.7326/M21-0909. Epub ahead of print. PMID: 34181449.

Coronary Artery Disease-associated and Longevity-associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living with HIV: The Swiss HIV Cohort Study. Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE; , for the Swiss HIV Cohort Study. Clin Infect Dis. 2021 Jun 6:ciab521. doi: 10.1093/cid/ciab521. Epub ahead of print. PMID: 34091660.

SARS-CoV-2 outbreak in a tri-national urban area is dominated by a B.1 lineage variant linked to a mass gathering event. Stange M, Mari A, Roloff T, Seth-Smith HM, Schweitzer M, Brunner M, Leuzinger K, Søgaard KK, Gensch A, Tschudin-Sutter S, Fuchs S, Bielicki J, Pargger H, Siegemund M, Nickel CH, Bingisser R, Osthoff M, Bassetti S, Schneider-Sliwa R, Battegay M, Hirsch HH, Egli A. PLoS Pathog. 2021 Mar 19;17(3):e1009374. doi: 10.1371/journal.ppat.1009374. Epub ahead of print. PMID: 33740028.

Evaluating antimicrobial effectiveness in environmental microbiology. Widmer AF, Frei R. Clin Infect Dis. 2021 Jan 10:ciab013. doi: 10.1093/cid/ciab013. Online ahead of print.

SARS-CoV-2 phylogeny during the early outbreak in the Basel area, Switzerland: import and spread dominated by a single B.1 lineage variant (C15324T) Madlen Stange, Alfredo Mari, Tim Roloff, Helena M. B. Seth-Smith, Michael Schweitzer, Myrta Brunner, Karoline Leuzinger, Kirstine K. Søgaard, Alexander Gensch, Sarah Tschudin-Sutter, Simon Fuchs, Julia Anna Bielicki, Hans Pargger, Martin Siegemund, Christian H. Nickel, Roland Bingisser, Michael Osthoff, Stefano Bassetti, Rita Schneider-Sliwa, Manuel Battegay, Hans H. Hirsch, Adrian Egli medRxiv 2020.09.01.20186155;

doi: doi.org/10.1101/2020.09.01.20186155

SARS-CoV-2 PCR testing of skin for COVID-19 diagnostics: a case report. Jamiolkowski D, Mühleisen B, Müller S, Navarini AA, Tzankov A, Roider E. Lancet. 2020 Aug 29;396(10251):598-599. doi: 10.1016/S0140-6736(20)31754-2. Epub 2020 Aug 13. PMID: 32798450

Dose-dependent effectiveness of acellular pertussis vaccine in infants: A population-based case-control study. Mack I, Erlanger TE, Lang P, Sinniger P, Perisa D, Heininger U. Vaccine. 2020 Feb 5;38(6):1444-1449. doi: 10.1016/j.vaccine.2019.11.069. Epub 2019 Dec 5.

Emergency management of status epilepticus in a high-fidelity simulation: A prospective study. Sutter R, Tisljar K, Opić P, De Marchis GM, Bassetti S, Bingisser R, Hunziker S, Marsch S. Neurology. 2019 Oct 8. pii: 10.1212/WNL.0000000000008461. doi: 10.1212/WNL.0000000000008461. [Epub ahead of print]